Combining casein phosphopeptide-amorphous calcium phosphate with fluoride

Synergistic remineralization potential of artificially demineralized enamel or not?

Iman Elsayad, Amal Sakr, Yahia Badr

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Abstract

Recaldent is a product of casein phosphopeptide-amorphous calcium phosphate (CPP - ACP). The remineralizing potential of CPP - ACP per se, or when combined with 0.22% Fl gel on artificially demineralized enamel using laser florescence, is investigated. Mesial surfaces of 15 sound human molars are tested using a He-Cd laser beam at 441.5nm with 18-mW power as an excitation source on a suitable setup based on a Spex 750-M monochromator provided with a photomultiplier tube (PMT) for detection of collected autofluorescence from sound enamel. Mesial surfaces are subjected to demineralization for ten days. The spectra from demineralized enamel are measured. Teeth are divided into three groups according to the remineralizing regimen: group 1 Recaldent per se, group 2 Recaldent combined with fluoride gel and ACP, and group 3 artificial saliva as a positive control. After following these protocols for three weeks, the spectra from the remineralized enamel are measured. The spectra of enamel autofluorescence are recorded and normalized to peak intensity at about 540nm to compare spectra from sound, demineralized, and remineralized enamel surfaces. A slight red shift occurred in spectra from demineralized enamel, while a blue shift may occur in remineralized enamel. Group 2 shows the highest remineralizing potential. Combining fluoride and ACP with CPP-ACP can give a synergistic effect on enamel remineralization.

Original languageEnglish
Article number044039
JournalJournal of Biomedical Optics
Volume14
Issue number4
DOIs
Publication statusPublished - 1 Dec 2009

Fingerprint

Phosphopeptides
Casein
enamels
calcium phosphates
Enamels
Calcium phosphate
Caseins
Fluorides
fluorides
Acoustic waves
acoustics
Gels
gels
Artificial Saliva
saliva
amorphous calcium phosphate
Monochromators
Photomultipliers
photomultiplier tubes
teeth

Keywords

  • artificial demineralization
  • casein phosphopeptide-amorphous calcium phosphate
  • fluoride
  • remineralization

Cite this

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title = "Combining casein phosphopeptide-amorphous calcium phosphate with fluoride: Synergistic remineralization potential of artificially demineralized enamel or not?",
abstract = "Recaldent is a product of casein phosphopeptide-amorphous calcium phosphate (CPP - ACP). The remineralizing potential of CPP - ACP per se, or when combined with 0.22{\%} Fl gel on artificially demineralized enamel using laser florescence, is investigated. Mesial surfaces of 15 sound human molars are tested using a He-Cd laser beam at 441.5nm with 18-mW power as an excitation source on a suitable setup based on a Spex 750-M monochromator provided with a photomultiplier tube (PMT) for detection of collected autofluorescence from sound enamel. Mesial surfaces are subjected to demineralization for ten days. The spectra from demineralized enamel are measured. Teeth are divided into three groups according to the remineralizing regimen: group 1 Recaldent per se, group 2 Recaldent combined with fluoride gel and ACP, and group 3 artificial saliva as a positive control. After following these protocols for three weeks, the spectra from the remineralized enamel are measured. The spectra of enamel autofluorescence are recorded and normalized to peak intensity at about 540nm to compare spectra from sound, demineralized, and remineralized enamel surfaces. A slight red shift occurred in spectra from demineralized enamel, while a blue shift may occur in remineralized enamel. Group 2 shows the highest remineralizing potential. Combining fluoride and ACP with CPP-ACP can give a synergistic effect on enamel remineralization.",
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Combining casein phosphopeptide-amorphous calcium phosphate with fluoride : Synergistic remineralization potential of artificially demineralized enamel or not? / Elsayad, Iman; Sakr, Amal; Badr, Yahia.

In: Journal of Biomedical Optics, Vol. 14, No. 4, 044039, 01.12.2009.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Combining casein phosphopeptide-amorphous calcium phosphate with fluoride

T2 - Synergistic remineralization potential of artificially demineralized enamel or not?

AU - Elsayad, Iman

AU - Sakr, Amal

AU - Badr, Yahia

PY - 2009/12/1

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N2 - Recaldent is a product of casein phosphopeptide-amorphous calcium phosphate (CPP - ACP). The remineralizing potential of CPP - ACP per se, or when combined with 0.22% Fl gel on artificially demineralized enamel using laser florescence, is investigated. Mesial surfaces of 15 sound human molars are tested using a He-Cd laser beam at 441.5nm with 18-mW power as an excitation source on a suitable setup based on a Spex 750-M monochromator provided with a photomultiplier tube (PMT) for detection of collected autofluorescence from sound enamel. Mesial surfaces are subjected to demineralization for ten days. The spectra from demineralized enamel are measured. Teeth are divided into three groups according to the remineralizing regimen: group 1 Recaldent per se, group 2 Recaldent combined with fluoride gel and ACP, and group 3 artificial saliva as a positive control. After following these protocols for three weeks, the spectra from the remineralized enamel are measured. The spectra of enamel autofluorescence are recorded and normalized to peak intensity at about 540nm to compare spectra from sound, demineralized, and remineralized enamel surfaces. A slight red shift occurred in spectra from demineralized enamel, while a blue shift may occur in remineralized enamel. Group 2 shows the highest remineralizing potential. Combining fluoride and ACP with CPP-ACP can give a synergistic effect on enamel remineralization.

AB - Recaldent is a product of casein phosphopeptide-amorphous calcium phosphate (CPP - ACP). The remineralizing potential of CPP - ACP per se, or when combined with 0.22% Fl gel on artificially demineralized enamel using laser florescence, is investigated. Mesial surfaces of 15 sound human molars are tested using a He-Cd laser beam at 441.5nm with 18-mW power as an excitation source on a suitable setup based on a Spex 750-M monochromator provided with a photomultiplier tube (PMT) for detection of collected autofluorescence from sound enamel. Mesial surfaces are subjected to demineralization for ten days. The spectra from demineralized enamel are measured. Teeth are divided into three groups according to the remineralizing regimen: group 1 Recaldent per se, group 2 Recaldent combined with fluoride gel and ACP, and group 3 artificial saliva as a positive control. After following these protocols for three weeks, the spectra from the remineralized enamel are measured. The spectra of enamel autofluorescence are recorded and normalized to peak intensity at about 540nm to compare spectra from sound, demineralized, and remineralized enamel surfaces. A slight red shift occurred in spectra from demineralized enamel, while a blue shift may occur in remineralized enamel. Group 2 shows the highest remineralizing potential. Combining fluoride and ACP with CPP-ACP can give a synergistic effect on enamel remineralization.

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