Determination of venlafaxine hydrochloride in biological fluids ‎using prepared ion selective electrode

Research output: Contribution to journalArticle

Abstract

A coated-wire ion selective electrode based on ion-pair complex of venlafaxine (VEN) with phosphomolybdic acid (PMA) as electroactive material in the presence of dioctylphthalate (DOP) as the plasticizing solvent mediator was prepared. The electrode showed a fast, stable and Nernstian response over a wide venlafaxine concentration range (1.0×10-5 to 1.0×10-2 mol L-1) with a slope of 58.70 mV dec-1 of concentration. The influences of membrane composition, temperature, pH of the test solution, and foreign ions on the electrode performance were investigated. The electrode was suitable for use in aqueous solutions in a wide pH range of 4.0 to 8.0. The standard electrode potentials, E°, were determined at different temperatures and used to calculate the isothermal temperature coefficient (dE°/dT) of the electrode. The proposed sensor displayed useful analytical characteristics for the determination of VEN in pure solutions and in biological fluids such as plasma and urine samples using the standard additions method.

Original languageEnglish
Article number42
Pages (from-to)244-248
Number of pages5
JournalInternational Journal of Pharmaceutical Sciences Review and Research
Volume37
Issue number2
Publication statusPublished - 1 Mar 2016

Fingerprint

Ion-Selective Electrodes
Electrodes
Temperature
Ions
Venlafaxine Hydrochloride
Urine
Membranes

Keywords

  • Biological fluids
  • Potentiometry
  • Venlafaxine hydrochloride (VEN)

Cite this

Al-Bedair, L. A. (2016). Determination of venlafaxine hydrochloride in biological fluids ‎using prepared ion selective electrode. International Journal of Pharmaceutical Sciences Review and Research, 37(2), 244-248. [42].
Al-Bedair, Lamia A. / Determination of venlafaxine hydrochloride in biological fluids ‎using prepared ion selective electrode. In: International Journal of Pharmaceutical Sciences Review and Research. 2016 ; Vol. 37, No. 2. pp. 244-248.
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Al-Bedair, LA 2016, 'Determination of venlafaxine hydrochloride in biological fluids ‎using prepared ion selective electrode', International Journal of Pharmaceutical Sciences Review and Research, vol. 37, no. 2, 42, pp. 244-248.

Determination of venlafaxine hydrochloride in biological fluids ‎using prepared ion selective electrode. / Al-Bedair, Lamia A.

In: International Journal of Pharmaceutical Sciences Review and Research, Vol. 37, No. 2, 42, 01.03.2016, p. 244-248.

Research output: Contribution to journalArticle

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Al-Bedair LA. Determination of venlafaxine hydrochloride in biological fluids ‎using prepared ion selective electrode. International Journal of Pharmaceutical Sciences Review and Research. 2016 Mar 1;37(2):244-248. 42.