Effect of olive leaf extract on glucose levels in diabetes-induced rats

A systematic review and meta-analysis

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Background: The present systematic review statistically analyzed randomized controlled trials on olive leaf extract (OLE) for effectiveness in managing glucose levels in diabetic rats. Methods: A literature search was performed using PubMed, the Cochrane Central Register of Controlled Trials, and EBSCO host databases. Selected articles, with no date restriction in the search process, were assessed independently by the authors using SYRCLE's risk of bias tool for animal studies. Data from eight trials on 162 rats were reviewed. Data were analyzed using Comprehensive Meta Analysis version 3.0. Results: Combined random effects analysis revealed that treatment of diabetic rats with OLE significantly increased insulin levels (standardized mean difference [SMD] 4.83 μIU/mL; 95% confidence interval [CI] 2.13, 7.54) and reduced blood glucose levels (SMD −4.21 mg/dL; 95% CI −5.75, −2.67). Secondary outcomes included significant reductions in total cholesterol and triglyceride levels, with a forest plot showing hypolipidemic effects among OLE-treated rats compared with placebo (SMD −6.32 mg/dL [95% CI −9.75, −2.88] and −4.22 mg/dL [95% CI −6.96, −1.48], respectively). There was no significant difference in body weight between OLE-treated rats and the placebo groups (SMD 0.46 g; 95% CI −0.05, 0.96; P = 0.98). Conclusion: Olive leaf extract is beneficial for both the lipid profile and glycemic control in diabetes-induced rats and may be as effective among humans.

Original languageEnglish
Pages (from-to)947-957
Number of pages11
JournalJournal of Diabetes
Volume9
Issue number10
DOIs
Publication statusPublished - 1 Oct 2017

Fingerprint

Olea
Meta-Analysis
Glucose
Confidence Intervals
Placebos
PubMed
Blood Glucose
Triglycerides
Randomized Controlled Trials
Cholesterol
Body Weight
Databases
Insulin
Lipids

Keywords

  • diabetes mellitus
  • glucose
  • lipid profile
  • olive leaf extract

Cite this

@article{2036a0fe0a86460b9dd67c9cac21cad5,
title = "Effect of olive leaf extract on glucose levels in diabetes-induced rats: A systematic review and meta-analysis",
abstract = "Background: The present systematic review statistically analyzed randomized controlled trials on olive leaf extract (OLE) for effectiveness in managing glucose levels in diabetic rats. Methods: A literature search was performed using PubMed, the Cochrane Central Register of Controlled Trials, and EBSCO host databases. Selected articles, with no date restriction in the search process, were assessed independently by the authors using SYRCLE's risk of bias tool for animal studies. Data from eight trials on 162 rats were reviewed. Data were analyzed using Comprehensive Meta Analysis version 3.0. Results: Combined random effects analysis revealed that treatment of diabetic rats with OLE significantly increased insulin levels (standardized mean difference [SMD] 4.83 μIU/mL; 95{\%} confidence interval [CI] 2.13, 7.54) and reduced blood glucose levels (SMD −4.21 mg/dL; 95{\%} CI −5.75, −2.67). Secondary outcomes included significant reductions in total cholesterol and triglyceride levels, with a forest plot showing hypolipidemic effects among OLE-treated rats compared with placebo (SMD −6.32 mg/dL [95{\%} CI −9.75, −2.88] and −4.22 mg/dL [95{\%} CI −6.96, −1.48], respectively). There was no significant difference in body weight between OLE-treated rats and the placebo groups (SMD 0.46 g; 95{\%} CI −0.05, 0.96; P = 0.98). Conclusion: Olive leaf extract is beneficial for both the lipid profile and glycemic control in diabetes-induced rats and may be as effective among humans.",
keywords = "diabetes mellitus, glucose, lipid profile, olive leaf extract",
author = "Hamzeh Abunab and Dator, {Wireen L.} and Sana Hawamdeh",
year = "2017",
month = "10",
day = "1",
doi = "10.1111/1753-0407.12508",
language = "English",
volume = "9",
pages = "947--957",
journal = "Journal of Diabetes",
issn = "1753-0393",
publisher = "Wiley-Blackwell",
number = "10",

}

Effect of olive leaf extract on glucose levels in diabetes-induced rats : A systematic review and meta-analysis. / Abunab, Hamzeh; Dator, Wireen L.; Hawamdeh, Sana.

In: Journal of Diabetes, Vol. 9, No. 10, 01.10.2017, p. 947-957.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Effect of olive leaf extract on glucose levels in diabetes-induced rats

T2 - A systematic review and meta-analysis

AU - Abunab, Hamzeh

AU - Dator, Wireen L.

AU - Hawamdeh, Sana

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Background: The present systematic review statistically analyzed randomized controlled trials on olive leaf extract (OLE) for effectiveness in managing glucose levels in diabetic rats. Methods: A literature search was performed using PubMed, the Cochrane Central Register of Controlled Trials, and EBSCO host databases. Selected articles, with no date restriction in the search process, were assessed independently by the authors using SYRCLE's risk of bias tool for animal studies. Data from eight trials on 162 rats were reviewed. Data were analyzed using Comprehensive Meta Analysis version 3.0. Results: Combined random effects analysis revealed that treatment of diabetic rats with OLE significantly increased insulin levels (standardized mean difference [SMD] 4.83 μIU/mL; 95% confidence interval [CI] 2.13, 7.54) and reduced blood glucose levels (SMD −4.21 mg/dL; 95% CI −5.75, −2.67). Secondary outcomes included significant reductions in total cholesterol and triglyceride levels, with a forest plot showing hypolipidemic effects among OLE-treated rats compared with placebo (SMD −6.32 mg/dL [95% CI −9.75, −2.88] and −4.22 mg/dL [95% CI −6.96, −1.48], respectively). There was no significant difference in body weight between OLE-treated rats and the placebo groups (SMD 0.46 g; 95% CI −0.05, 0.96; P = 0.98). Conclusion: Olive leaf extract is beneficial for both the lipid profile and glycemic control in diabetes-induced rats and may be as effective among humans.

AB - Background: The present systematic review statistically analyzed randomized controlled trials on olive leaf extract (OLE) for effectiveness in managing glucose levels in diabetic rats. Methods: A literature search was performed using PubMed, the Cochrane Central Register of Controlled Trials, and EBSCO host databases. Selected articles, with no date restriction in the search process, were assessed independently by the authors using SYRCLE's risk of bias tool for animal studies. Data from eight trials on 162 rats were reviewed. Data were analyzed using Comprehensive Meta Analysis version 3.0. Results: Combined random effects analysis revealed that treatment of diabetic rats with OLE significantly increased insulin levels (standardized mean difference [SMD] 4.83 μIU/mL; 95% confidence interval [CI] 2.13, 7.54) and reduced blood glucose levels (SMD −4.21 mg/dL; 95% CI −5.75, −2.67). Secondary outcomes included significant reductions in total cholesterol and triglyceride levels, with a forest plot showing hypolipidemic effects among OLE-treated rats compared with placebo (SMD −6.32 mg/dL [95% CI −9.75, −2.88] and −4.22 mg/dL [95% CI −6.96, −1.48], respectively). There was no significant difference in body weight between OLE-treated rats and the placebo groups (SMD 0.46 g; 95% CI −0.05, 0.96; P = 0.98). Conclusion: Olive leaf extract is beneficial for both the lipid profile and glycemic control in diabetes-induced rats and may be as effective among humans.

KW - diabetes mellitus

KW - glucose

KW - lipid profile

KW - olive leaf extract

UR - http://www.scopus.com/inward/record.url?scp=85007317079&partnerID=8YFLogxK

U2 - 10.1111/1753-0407.12508

DO - 10.1111/1753-0407.12508

M3 - Article

VL - 9

SP - 947

EP - 957

JO - Journal of Diabetes

JF - Journal of Diabetes

SN - 1753-0393

IS - 10

ER -