Effects of hormonal contraception on plasma lipid and lipoprotein cholesterol concentrations

Sadiqa Syed, Masood A. Qureshi

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

Objective: To evaluate the cardiovascular risk factors in Design: The study was carried out prospectively on 70 women aged between 20-45 years and compared with 10 age-matched controls. Place and Duration of Study: The study was conducted at Jinnah Postgraduate Medical Center and KMC Maternity Home, PIB Colony, Karachi and the period of study was 18 months. Patients and Methods: Eighty women with low socio-economic status were selected. They were either uneducated or informally educated and were classified as controls (n=10), oral contraceptive users (OC; n=35) and injectable users (IC; n=35). Contraceptives in practice were: oral tablet Lofemenal and Nordette, and injectables Norigest and implant Norplant. Blood sampling was done in overnight fasting condition and serum total cholesterol (TC), triglycerides (TG), and high-density lipoprotein (HDL-C) were determined by enzymatic colorimetric method, whereas low density (LDL-C), very low-density lipoprotein (VLDL-C) and atherogenic index were calculated by Friedwald s formula. Results: Lipid metabolite levels in both the groups of contraceptive users showed fluctuations. Borderline and high risk total cholesterol levels were observed in 40% and 13% oral and injectable users respectively, whereas decrease in HDL-C levels was noted in contraceptive users as compared to the controls. Serum TG, LDL-C and VLDL-C did not show significant variations among these groups. Conclusion: Oral and injectable contraceptives of second generation may result in alteration in lipid profiles, though insignificant, when used for long-term (> 3 years). However, short-term use, on the other hand, particularly in the absence of cardiovascular risk factor seems acceptable.

Original languageEnglish
Pages (from-to)593-598
Number of pages6
JournalJournal of the College of Physicians and Surgeons Pakistan
Volume12
Issue number10
Publication statusPublished - 1 Oct 2002

Fingerprint

Contraception
Contraceptive Agents
Lipids
Injections
Oral Contraceptives
Ethinyl Estradiol-Norgestrel Combination
Levonorgestrel
VLDL Lipoproteins
Serum
HDL Cholesterol
Tablets
Fasting
Triglycerides
Cholesterol
Economics
lipoprotein cholesterol

Keywords

  • Atherogenic index (AI)
  • Cardiovascular disease (CVD)
  • High-Density lipoprotein cholesterol (HDL-C)
  • Injectable contraceptives (IC)
  • Low density lipoprotein cholesterol (LDL-C)
  • Oral contraceptives (OC)
  • Triglycerides (TG)
  • Very low-Density lipoprotein cholesterol (VLDL-C)

Cite this

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title = "Effects of hormonal contraception on plasma lipid and lipoprotein cholesterol concentrations",
abstract = "Objective: To evaluate the cardiovascular risk factors in Design: The study was carried out prospectively on 70 women aged between 20-45 years and compared with 10 age-matched controls. Place and Duration of Study: The study was conducted at Jinnah Postgraduate Medical Center and KMC Maternity Home, PIB Colony, Karachi and the period of study was 18 months. Patients and Methods: Eighty women with low socio-economic status were selected. They were either uneducated or informally educated and were classified as controls (n=10), oral contraceptive users (OC; n=35) and injectable users (IC; n=35). Contraceptives in practice were: oral tablet Lofemenal and Nordette, and injectables Norigest and implant Norplant. Blood sampling was done in overnight fasting condition and serum total cholesterol (TC), triglycerides (TG), and high-density lipoprotein (HDL-C) were determined by enzymatic colorimetric method, whereas low density (LDL-C), very low-density lipoprotein (VLDL-C) and atherogenic index were calculated by Friedwald s formula. Results: Lipid metabolite levels in both the groups of contraceptive users showed fluctuations. Borderline and high risk total cholesterol levels were observed in 40{\%} and 13{\%} oral and injectable users respectively, whereas decrease in HDL-C levels was noted in contraceptive users as compared to the controls. Serum TG, LDL-C and VLDL-C did not show significant variations among these groups. Conclusion: Oral and injectable contraceptives of second generation may result in alteration in lipid profiles, though insignificant, when used for long-term (> 3 years). However, short-term use, on the other hand, particularly in the absence of cardiovascular risk factor seems acceptable.",
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Effects of hormonal contraception on plasma lipid and lipoprotein cholesterol concentrations. / Syed, Sadiqa; Qureshi, Masood A.

In: Journal of the College of Physicians and Surgeons Pakistan, Vol. 12, No. 10, 01.10.2002, p. 593-598.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Effects of hormonal contraception on plasma lipid and lipoprotein cholesterol concentrations

AU - Syed, Sadiqa

AU - Qureshi, Masood A.

PY - 2002/10/1

Y1 - 2002/10/1

N2 - Objective: To evaluate the cardiovascular risk factors in Design: The study was carried out prospectively on 70 women aged between 20-45 years and compared with 10 age-matched controls. Place and Duration of Study: The study was conducted at Jinnah Postgraduate Medical Center and KMC Maternity Home, PIB Colony, Karachi and the period of study was 18 months. Patients and Methods: Eighty women with low socio-economic status were selected. They were either uneducated or informally educated and were classified as controls (n=10), oral contraceptive users (OC; n=35) and injectable users (IC; n=35). Contraceptives in practice were: oral tablet Lofemenal and Nordette, and injectables Norigest and implant Norplant. Blood sampling was done in overnight fasting condition and serum total cholesterol (TC), triglycerides (TG), and high-density lipoprotein (HDL-C) were determined by enzymatic colorimetric method, whereas low density (LDL-C), very low-density lipoprotein (VLDL-C) and atherogenic index were calculated by Friedwald s formula. Results: Lipid metabolite levels in both the groups of contraceptive users showed fluctuations. Borderline and high risk total cholesterol levels were observed in 40% and 13% oral and injectable users respectively, whereas decrease in HDL-C levels was noted in contraceptive users as compared to the controls. Serum TG, LDL-C and VLDL-C did not show significant variations among these groups. Conclusion: Oral and injectable contraceptives of second generation may result in alteration in lipid profiles, though insignificant, when used for long-term (> 3 years). However, short-term use, on the other hand, particularly in the absence of cardiovascular risk factor seems acceptable.

AB - Objective: To evaluate the cardiovascular risk factors in Design: The study was carried out prospectively on 70 women aged between 20-45 years and compared with 10 age-matched controls. Place and Duration of Study: The study was conducted at Jinnah Postgraduate Medical Center and KMC Maternity Home, PIB Colony, Karachi and the period of study was 18 months. Patients and Methods: Eighty women with low socio-economic status were selected. They were either uneducated or informally educated and were classified as controls (n=10), oral contraceptive users (OC; n=35) and injectable users (IC; n=35). Contraceptives in practice were: oral tablet Lofemenal and Nordette, and injectables Norigest and implant Norplant. Blood sampling was done in overnight fasting condition and serum total cholesterol (TC), triglycerides (TG), and high-density lipoprotein (HDL-C) were determined by enzymatic colorimetric method, whereas low density (LDL-C), very low-density lipoprotein (VLDL-C) and atherogenic index were calculated by Friedwald s formula. Results: Lipid metabolite levels in both the groups of contraceptive users showed fluctuations. Borderline and high risk total cholesterol levels were observed in 40% and 13% oral and injectable users respectively, whereas decrease in HDL-C levels was noted in contraceptive users as compared to the controls. Serum TG, LDL-C and VLDL-C did not show significant variations among these groups. Conclusion: Oral and injectable contraceptives of second generation may result in alteration in lipid profiles, though insignificant, when used for long-term (> 3 years). However, short-term use, on the other hand, particularly in the absence of cardiovascular risk factor seems acceptable.

KW - Atherogenic index (AI)

KW - Cardiovascular disease (CVD)

KW - High-Density lipoprotein cholesterol (HDL-C)

KW - Injectable contraceptives (IC)

KW - Low density lipoprotein cholesterol (LDL-C)

KW - Oral contraceptives (OC)

KW - Triglycerides (TG)

KW - Very low-Density lipoprotein cholesterol (VLDL-C)

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M3 - Article

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SN - 1022-386X

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