Efficacy of two praziquantel treatments among primary school children in an area of high Schistosoma mansoni endemicity, Nile Delta, Egypt

Rashida Barakat, Hala El Morshedy

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Abstract

Praziquantel is the cornerstone of schistosomiasis control. A number of reports from endemic areas suggest that resistance or tolerance to praziquantel might exist in Schistosoma mansoni. Several explanations were postulated. The present work was designed to test the hypothesis that a low praziquantel (pzq) cure rate in Egypt is due to survival and maturation of immature stages that escaped pzq, which is effective against mature S. mansoni worms only. The study sample included 1351 children attending El Rouse primary school located in El Rouse village, Nile Delta, Egypt. All children received 2 pzq doses (40 mg/kg) 4 weeks apart. Diagnosis of S. mansoni infection and cure assessment were based on examination of 2 Kato slides prepared from a single stool sample collected before and 4 weeks after the first and second treatments. The cure rate was 788% after the first treatment and increased significantly to 908% after the second treatment. Egg reduction rates were 712% and 772% after 1 and 2 treatments respectively. Pre-treatment intensity of infection has a great influence on cure and egg reduction rates. Our results confirmed that low praziquantel cure rate, in Egypt, might be attributed, even partially, to survival and maturation of the immature S. mansoni stages that escaped pzq that is effective against mature worms only.

Original languageEnglish
Pages (from-to)440-446
Number of pages7
JournalParasitology
Volume138
Issue number4
DOIs
Publication statusPublished - 1 Apr 2011

Fingerprint

praziquantel
Praziquantel
elementary schools
school children
Schistosoma mansoni
Egypt
indigenous species
Therapeutics
Ovum
immatures
Schistosomiasis mansoni
schistosomiasis
Schistosomiasis
infection
villages
pretreatment
sampling
dosage
Infection

Keywords

  • cure rate
  • egg reduction rate
  • Egypt
  • praziquantel
  • Schistosoma mansoni
  • schistosomiasis

Cite this

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title = "Efficacy of two praziquantel treatments among primary school children in an area of high Schistosoma mansoni endemicity, Nile Delta, Egypt",
abstract = "Praziquantel is the cornerstone of schistosomiasis control. A number of reports from endemic areas suggest that resistance or tolerance to praziquantel might exist in Schistosoma mansoni. Several explanations were postulated. The present work was designed to test the hypothesis that a low praziquantel (pzq) cure rate in Egypt is due to survival and maturation of immature stages that escaped pzq, which is effective against mature S. mansoni worms only. The study sample included 1351 children attending El Rouse primary school located in El Rouse village, Nile Delta, Egypt. All children received 2 pzq doses (40 mg/kg) 4 weeks apart. Diagnosis of S. mansoni infection and cure assessment were based on examination of 2 Kato slides prepared from a single stool sample collected before and 4 weeks after the first and second treatments. The cure rate was 788{\%} after the first treatment and increased significantly to 908{\%} after the second treatment. Egg reduction rates were 712{\%} and 772{\%} after 1 and 2 treatments respectively. Pre-treatment intensity of infection has a great influence on cure and egg reduction rates. Our results confirmed that low praziquantel cure rate, in Egypt, might be attributed, even partially, to survival and maturation of the immature S. mansoni stages that escaped pzq that is effective against mature worms only.",
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Efficacy of two praziquantel treatments among primary school children in an area of high Schistosoma mansoni endemicity, Nile Delta, Egypt. / Barakat, Rashida; Morshedy, Hala El.

In: Parasitology, Vol. 138, No. 4, 01.04.2011, p. 440-446.

Research output: Contribution to journalArticleResearchpeer-review

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