Feasibility of diffusion weighted MR imaging in differentiating recurrent laryngeal carcinoma from radionecrosis

Ghada K. Gouhar, Mona A. El-Hariri

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Abstract

Purpose: To assess the feasibility of apparent diffusion coefficient (ADC) generated from diffusion weighted magnetic resonance imaging as a non invasive technique to differentiate tumor recurrence from radionecrosis in patients with laryngeal carcinoma. Materials and methods: Twenty one patients suspected of tumor recurrence underwent MRI including diffusion weighted imaging (DWI) (b 0 and 1000). ADC maps were generated and ADC values were measured at the lesion sites and the normal laryngeal tissues, and were compared with the histopathological results. Results: The mean ADC of tumor recurrence {1.04 ± 0.34 × 10-3 mm2/s (SD)} was significantly lower (p < 0.0001) than the mean ADC of the normal laryngeal tissues in the same patient (1.48 ± 0.099 × 10-3 mm2/s) while the mean ADC of radionecrosis (1.79 ± 0.41 × 10-3 mm2/s) was significantly higher (p < 0.04) than the mean ADC of the normal laryngeal tissues (1.49 ± 0.095 × 10-3 mm2). The mean ADC of tumor recurrence is significantly lower (p < 0.0001) than the mean ADC of radionecrosis with 1.16 × 10-3 mm2/s is the best cut value for differentiating tumor recurrence from radionecrosis. Conclusion: ADC can differentiate tumor recurrence from radionecrosis in laryngeal carcinoma.

Original languageEnglish
Pages (from-to)169-175
Number of pages7
JournalEgyptian Journal of Radiology and Nuclear Medicine
Volume42
Issue number2
DOIs
Publication statusPublished - 1 Jun 2011

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Carcinoma
Recurrence
Neoplasms
Diffusion Magnetic Resonance Imaging

Keywords

  • ADC
  • DWI
  • Laryngeal carcinoma
  • Radionecrosis
  • Tumor recurrence

Cite this

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abstract = "Purpose: To assess the feasibility of apparent diffusion coefficient (ADC) generated from diffusion weighted magnetic resonance imaging as a non invasive technique to differentiate tumor recurrence from radionecrosis in patients with laryngeal carcinoma. Materials and methods: Twenty one patients suspected of tumor recurrence underwent MRI including diffusion weighted imaging (DWI) (b 0 and 1000). ADC maps were generated and ADC values were measured at the lesion sites and the normal laryngeal tissues, and were compared with the histopathological results. Results: The mean ADC of tumor recurrence {1.04 ± 0.34 × 10-3 mm2/s (SD)} was significantly lower (p < 0.0001) than the mean ADC of the normal laryngeal tissues in the same patient (1.48 ± 0.099 × 10-3 mm2/s) while the mean ADC of radionecrosis (1.79 ± 0.41 × 10-3 mm2/s) was significantly higher (p < 0.04) than the mean ADC of the normal laryngeal tissues (1.49 ± 0.095 × 10-3 mm2). The mean ADC of tumor recurrence is significantly lower (p < 0.0001) than the mean ADC of radionecrosis with 1.16 × 10-3 mm2/s is the best cut value for differentiating tumor recurrence from radionecrosis. Conclusion: ADC can differentiate tumor recurrence from radionecrosis in laryngeal carcinoma.",
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Feasibility of diffusion weighted MR imaging in differentiating recurrent laryngeal carcinoma from radionecrosis. / Gouhar, Ghada K.; El-Hariri, Mona A.

In: Egyptian Journal of Radiology and Nuclear Medicine, Vol. 42, No. 2, 01.06.2011, p. 169-175.

Research output: Contribution to journalArticleResearchpeer-review

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N2 - Purpose: To assess the feasibility of apparent diffusion coefficient (ADC) generated from diffusion weighted magnetic resonance imaging as a non invasive technique to differentiate tumor recurrence from radionecrosis in patients with laryngeal carcinoma. Materials and methods: Twenty one patients suspected of tumor recurrence underwent MRI including diffusion weighted imaging (DWI) (b 0 and 1000). ADC maps were generated and ADC values were measured at the lesion sites and the normal laryngeal tissues, and were compared with the histopathological results. Results: The mean ADC of tumor recurrence {1.04 ± 0.34 × 10-3 mm2/s (SD)} was significantly lower (p < 0.0001) than the mean ADC of the normal laryngeal tissues in the same patient (1.48 ± 0.099 × 10-3 mm2/s) while the mean ADC of radionecrosis (1.79 ± 0.41 × 10-3 mm2/s) was significantly higher (p < 0.04) than the mean ADC of the normal laryngeal tissues (1.49 ± 0.095 × 10-3 mm2). The mean ADC of tumor recurrence is significantly lower (p < 0.0001) than the mean ADC of radionecrosis with 1.16 × 10-3 mm2/s is the best cut value for differentiating tumor recurrence from radionecrosis. Conclusion: ADC can differentiate tumor recurrence from radionecrosis in laryngeal carcinoma.

AB - Purpose: To assess the feasibility of apparent diffusion coefficient (ADC) generated from diffusion weighted magnetic resonance imaging as a non invasive technique to differentiate tumor recurrence from radionecrosis in patients with laryngeal carcinoma. Materials and methods: Twenty one patients suspected of tumor recurrence underwent MRI including diffusion weighted imaging (DWI) (b 0 and 1000). ADC maps were generated and ADC values were measured at the lesion sites and the normal laryngeal tissues, and were compared with the histopathological results. Results: The mean ADC of tumor recurrence {1.04 ± 0.34 × 10-3 mm2/s (SD)} was significantly lower (p < 0.0001) than the mean ADC of the normal laryngeal tissues in the same patient (1.48 ± 0.099 × 10-3 mm2/s) while the mean ADC of radionecrosis (1.79 ± 0.41 × 10-3 mm2/s) was significantly higher (p < 0.04) than the mean ADC of the normal laryngeal tissues (1.49 ± 0.095 × 10-3 mm2). The mean ADC of tumor recurrence is significantly lower (p < 0.0001) than the mean ADC of radionecrosis with 1.16 × 10-3 mm2/s is the best cut value for differentiating tumor recurrence from radionecrosis. Conclusion: ADC can differentiate tumor recurrence from radionecrosis in laryngeal carcinoma.

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