Helicobacter pylori

An overview on antimicrobials and drug delivery systems for its eradication

Sally A. El-Zahaby, Abeer A. Kassem, Amal H. El-Kamel

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Since the discovery of Helicobacter pylori (H. pylori) in the early 1980s, its eradication has been one of the most important global challenges in gastroenterology. Various circumstances make the treatment with antimicrobials particularly difficult. One problem has been that antibiotics commonly used were designed for the treatment of infections throughout the body rather than for delivering high concentrations locally within the stomach. Many gastroretentive dosage forms were developed in order to eradicate the infection, yet additional advancements are still needed to eliminate the infection completely and decrease its prevalence worldwide. An overview on different antimicrobials and a literature survey about different drug delivery systems used in eradication of H. pylori infection are presented in this review.

Original languageEnglish
Pages (from-to)306-312
Number of pages7
JournalCurrent Drug Delivery
Volume11
Issue number3
DOIs
Publication statusPublished - 1 Jan 2014

Fingerprint

Drug Delivery Systems
Helicobacter pylori
Infection
Dosage Forms
Helicobacter Infections
Gastroenterology
Stomach
Anti-Bacterial Agents
Therapeutics

Keywords

  • Gastroretentive
  • Helicobacter pylori
  • Mucopenetration
  • Specific targeting

Cite this

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Helicobacter pylori : An overview on antimicrobials and drug delivery systems for its eradication. / El-Zahaby, Sally A.; Kassem, Abeer A.; El-Kamel, Amal H.

In: Current Drug Delivery, Vol. 11, No. 3, 01.01.2014, p. 306-312.

Research output: Contribution to journalArticleResearchpeer-review

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