Modulation of glutathione, phospholipids and lipid peroxides liver contents induced by zinc oxide nanoparticles using natural antioxidants

N. M. Al-Rasheed, L. M. Fadda, H. M. Ali, N. A. Abdel Baky

Research output: Contribution to journalArticleResearchpeer-review

Abstract

With increasing industrial production of engineered nanoparticles, questions have been raised about their effects on human and animals. So the objective of this study is to detect the prophylactic role of either α-lipoic acid (α-lip) or vitamin E (vit E) against the hepatotoxic effect of Zinc oxide nanoparticles (ZnO-NPs) 50-nm induced metabolic disorder. ZnO-NPs were administered orally using two doses (600 mg and 1 g/kg body weight/day for 5 consecutive days). ZnO-NPs exhibited a marked increase in serum ALT and lipid peroxide (LP) as well as total phospholipids (PL), phosphatidylcholine, phosphatidylethanolamine levels while the liver content of reduced glutathione (GHS) and sphingomyelin as well as triglycerides levels was decreased compared with normal control group. Concurrent treatment of rats with either α-lip (200 mg/kg body weight) or vit E (100 mg/kg body weight) daily for three weeks to ZnO-NPs intoxicated rats significantly alleviated most of the deviated previous biochemical parameters. It was concluded that the decline in sphingomyelin content may be considered as a novel mechanism for ZnONPs, it has an apoptotic action and the treatment with either the aforementioned antioxidants has a beneficial effect.

Original languageEnglish
Pages (from-to)303-312
Number of pages10
JournalDigest Journal of Nanomaterials and Biostructures
Volume11
Issue number1
Publication statusPublished - 1 Jan 2016

Fingerprint

Zinc Oxide
glutathione
Lipid Peroxides
Phospholipids
antioxidants
peroxides
Zinc oxide
Antioxidants
liver
Liver
zinc oxides
Nanoparticles
Glutathione
lipids
body weight
Modulation
modulation
nanoparticles
tocopherol
Sphingomyelins

Keywords

  • Glutathione
  • Phospholipids
  • Vitamin E
  • Zinc oxide nanoparticles
  • α-lipoic acid

Cite this

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title = "Modulation of glutathione, phospholipids and lipid peroxides liver contents induced by zinc oxide nanoparticles using natural antioxidants",
abstract = "With increasing industrial production of engineered nanoparticles, questions have been raised about their effects on human and animals. So the objective of this study is to detect the prophylactic role of either α-lipoic acid (α-lip) or vitamin E (vit E) against the hepatotoxic effect of Zinc oxide nanoparticles (ZnO-NPs) 50-nm induced metabolic disorder. ZnO-NPs were administered orally using two doses (600 mg and 1 g/kg body weight/day for 5 consecutive days). ZnO-NPs exhibited a marked increase in serum ALT and lipid peroxide (LP) as well as total phospholipids (PL), phosphatidylcholine, phosphatidylethanolamine levels while the liver content of reduced glutathione (GHS) and sphingomyelin as well as triglycerides levels was decreased compared with normal control group. Concurrent treatment of rats with either α-lip (200 mg/kg body weight) or vit E (100 mg/kg body weight) daily for three weeks to ZnO-NPs intoxicated rats significantly alleviated most of the deviated previous biochemical parameters. It was concluded that the decline in sphingomyelin content may be considered as a novel mechanism for ZnONPs, it has an apoptotic action and the treatment with either the aforementioned antioxidants has a beneficial effect.",
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Modulation of glutathione, phospholipids and lipid peroxides liver contents induced by zinc oxide nanoparticles using natural antioxidants. / Al-Rasheed, N. M.; Fadda, L. M.; Ali, H. M.; Abdel Baky, N. A.

In: Digest Journal of Nanomaterials and Biostructures, Vol. 11, No. 1, 01.01.2016, p. 303-312.

Research output: Contribution to journalArticleResearchpeer-review

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