Near-Infrared Triggered Decomposition of Nanocapsules with High Tumor Accumulation and Stimuli Responsive Fast Elimination

Tiancong Zhao, Peiyuan Wang, Qin Li, Areej Abdulkareem Al-Khalaf, Wael N. Hozzein, Fan Zhang, Xiaomin Li, Dongyuan Zhao

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Abstract

A near-infrared (NIR) induced decomposable polymer nanocapsule is demonstrated. The nanocapsules are fabricated based on layer-by-layer co-assembly of azobenzene functionalized polymers and up/downconversion nanoparticles (U/DCNPs). When the nanocapsules are exposed to 980 nm light, ultraviolet/visible photons emitted by the U/DCNPs can trigger the photoisomerization of azobenzene groups in the framework. The nanocapsules could decompose from large-sized nanocapsule to small U/DCNPs. Owing to their optimized original size (ca. 180 nm), the nanocapsules can effectively avoid biological barriers, provide a long blood circulation (ca. 5 h, half-life time) and achieve four-fold tumor accumulation. It can fast eliminate from tumor within one hour and release the loaded drugs for chemotherapy after NIR-induced dissociation from initial 180 nm capsules to small 20 nm U/DCNPs.

Original languageEnglish
Pages (from-to)2611-2615
Number of pages5
JournalAngewandte Chemie - International Edition
Volume57
Issue number10
DOIs
Publication statusPublished - 1 Mar 2018

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Nanocapsules
Tumors
Infrared radiation
Decomposition
Nanoparticles
Azobenzene
Polymers
Photoisomerization
Chemotherapy
Hemodynamics
Capsules
Photons
Pharmaceutical Preparations

Keywords

  • core–shell structure
  • drug delivery
  • nanocapsules
  • nanoparticles
  • upconversion

Cite this

Zhao, Tiancong ; Wang, Peiyuan ; Li, Qin ; Al-Khalaf, Areej Abdulkareem ; Hozzein, Wael N. ; Zhang, Fan ; Li, Xiaomin ; Zhao, Dongyuan. / Near-Infrared Triggered Decomposition of Nanocapsules with High Tumor Accumulation and Stimuli Responsive Fast Elimination. In: Angewandte Chemie - International Edition. 2018 ; Vol. 57, No. 10. pp. 2611-2615.
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Near-Infrared Triggered Decomposition of Nanocapsules with High Tumor Accumulation and Stimuli Responsive Fast Elimination. / Zhao, Tiancong; Wang, Peiyuan; Li, Qin; Al-Khalaf, Areej Abdulkareem; Hozzein, Wael N.; Zhang, Fan; Li, Xiaomin; Zhao, Dongyuan.

In: Angewandte Chemie - International Edition, Vol. 57, No. 10, 01.03.2018, p. 2611-2615.

Research output: Contribution to journalArticleResearchpeer-review

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