Possible protective mechanisms exerted by metformin or metformin and vitamin E in isoproterenol-induced cardiac injury

Nawal M. Al-Rasheed, Nouf M. Al-Rasheed, Danah A. AL-Rabeeah, Heba S. AL-Barrak, Salma A. AL-Salman, Shahd A. Ibrahim, Sulafa A. AL-Hassab, Maha A. Al-Amin, Iman H. Hasan, Hanaa N. Al-Ajmi, Tahani K. AL-Shammari

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1 Citation (Scopus)

Abstract

Several studies have reported that metformin is cardioprotective for diabetic and non-diabetic ischemic hearts through mechanisms that cannot be entirely attributed to its anti-hyperglycemic effect. This study was designed to investigate the cardioprotective effects of metformin with and without vitamin E after induction myocardial infarction (MI) in rats, using isoproterenol. Administration of metformin or vitamin E significantly reduced the cardiac mass index (P < 0.01), ameliorated the changes to cardiac biomarkers, and attenuated oxidative stress levels compared to the isoproterenol group. Interestingly, combination therapy showed a slight synergistic effect. Histopathological analysis suggested that metformin treatment reduced NF-κB expression and protected against isoproterenol-induced MI. Our results indicate that metformin mediates a cardioprotective effect against isoproterenol-induced MI via antioxidant activity and modulation of the NF-κB signaling pathway. This suggests that metformin would be beneficial in MI treatment.

Original languageEnglish
Pages (from-to)3903-3912
Number of pages10
JournalJournal of Cellular Biochemistry
Volume119
Issue number5
DOIs
Publication statusPublished - 1 May 2018

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Metformin
Vitamin E
Isoproterenol
Wounds and Injuries
Myocardial Infarction
Oxidative stress
Biomarkers
Rats
Oxidative Stress
Antioxidants
Modulation

Keywords

  • cardioprotection
  • metformin
  • myocardial infarction
  • NF κB
  • oxidative stress
  • vitamin E

Cite this

Al-Rasheed, N. M., Al-Rasheed, N. M., AL-Rabeeah, D. A., AL-Barrak, H. S., AL-Salman, S. A., Ibrahim, S. A., ... AL-Shammari, T. K. (2018). Possible protective mechanisms exerted by metformin or metformin and vitamin E in isoproterenol-induced cardiac injury. Journal of Cellular Biochemistry, 119(5), 3903-3912. https://doi.org/10.1002/jcb.26530
Al-Rasheed, Nawal M. ; Al-Rasheed, Nouf M. ; AL-Rabeeah, Danah A. ; AL-Barrak, Heba S. ; AL-Salman, Salma A. ; Ibrahim, Shahd A. ; AL-Hassab, Sulafa A. ; Al-Amin, Maha A. ; Hasan, Iman H. ; Al-Ajmi, Hanaa N. ; AL-Shammari, Tahani K. / Possible protective mechanisms exerted by metformin or metformin and vitamin E in isoproterenol-induced cardiac injury. In: Journal of Cellular Biochemistry. 2018 ; Vol. 119, No. 5. pp. 3903-3912.
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abstract = "Several studies have reported that metformin is cardioprotective for diabetic and non-diabetic ischemic hearts through mechanisms that cannot be entirely attributed to its anti-hyperglycemic effect. This study was designed to investigate the cardioprotective effects of metformin with and without vitamin E after induction myocardial infarction (MI) in rats, using isoproterenol. Administration of metformin or vitamin E significantly reduced the cardiac mass index (P < 0.01), ameliorated the changes to cardiac biomarkers, and attenuated oxidative stress levels compared to the isoproterenol group. Interestingly, combination therapy showed a slight synergistic effect. Histopathological analysis suggested that metformin treatment reduced NF-κB expression and protected against isoproterenol-induced MI. Our results indicate that metformin mediates a cardioprotective effect against isoproterenol-induced MI via antioxidant activity and modulation of the NF-κB signaling pathway. This suggests that metformin would be beneficial in MI treatment.",
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Al-Rasheed, NM, Al-Rasheed, NM, AL-Rabeeah, DA, AL-Barrak, HS, AL-Salman, SA, Ibrahim, SA, AL-Hassab, SA, Al-Amin, MA, Hasan, IH, Al-Ajmi, HN & AL-Shammari, TK 2018, 'Possible protective mechanisms exerted by metformin or metformin and vitamin E in isoproterenol-induced cardiac injury', Journal of Cellular Biochemistry, vol. 119, no. 5, pp. 3903-3912. https://doi.org/10.1002/jcb.26530

Possible protective mechanisms exerted by metformin or metformin and vitamin E in isoproterenol-induced cardiac injury. / Al-Rasheed, Nawal M.; Al-Rasheed, Nouf M.; AL-Rabeeah, Danah A.; AL-Barrak, Heba S.; AL-Salman, Salma A.; Ibrahim, Shahd A.; AL-Hassab, Sulafa A.; Al-Amin, Maha A.; Hasan, Iman H.; Al-Ajmi, Hanaa N.; AL-Shammari, Tahani K.

In: Journal of Cellular Biochemistry, Vol. 119, No. 5, 01.05.2018, p. 3903-3912.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Possible protective mechanisms exerted by metformin or metformin and vitamin E in isoproterenol-induced cardiac injury

AU - Al-Rasheed, Nawal M.

AU - Al-Rasheed, Nouf M.

AU - AL-Rabeeah, Danah A.

AU - AL-Barrak, Heba S.

AU - AL-Salman, Salma A.

AU - Ibrahim, Shahd A.

AU - AL-Hassab, Sulafa A.

AU - Al-Amin, Maha A.

AU - Hasan, Iman H.

AU - Al-Ajmi, Hanaa N.

AU - AL-Shammari, Tahani K.

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Several studies have reported that metformin is cardioprotective for diabetic and non-diabetic ischemic hearts through mechanisms that cannot be entirely attributed to its anti-hyperglycemic effect. This study was designed to investigate the cardioprotective effects of metformin with and without vitamin E after induction myocardial infarction (MI) in rats, using isoproterenol. Administration of metformin or vitamin E significantly reduced the cardiac mass index (P < 0.01), ameliorated the changes to cardiac biomarkers, and attenuated oxidative stress levels compared to the isoproterenol group. Interestingly, combination therapy showed a slight synergistic effect. Histopathological analysis suggested that metformin treatment reduced NF-κB expression and protected against isoproterenol-induced MI. Our results indicate that metformin mediates a cardioprotective effect against isoproterenol-induced MI via antioxidant activity and modulation of the NF-κB signaling pathway. This suggests that metformin would be beneficial in MI treatment.

AB - Several studies have reported that metformin is cardioprotective for diabetic and non-diabetic ischemic hearts through mechanisms that cannot be entirely attributed to its anti-hyperglycemic effect. This study was designed to investigate the cardioprotective effects of metformin with and without vitamin E after induction myocardial infarction (MI) in rats, using isoproterenol. Administration of metformin or vitamin E significantly reduced the cardiac mass index (P < 0.01), ameliorated the changes to cardiac biomarkers, and attenuated oxidative stress levels compared to the isoproterenol group. Interestingly, combination therapy showed a slight synergistic effect. Histopathological analysis suggested that metformin treatment reduced NF-κB expression and protected against isoproterenol-induced MI. Our results indicate that metformin mediates a cardioprotective effect against isoproterenol-induced MI via antioxidant activity and modulation of the NF-κB signaling pathway. This suggests that metformin would be beneficial in MI treatment.

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