Potential protective effects of Nigella sativaand allium sativum against fructose-induced metabolic syndrome in rats

Nawal Al-Rasheed, Nouf Al-Rasheed, Yieldez Bassiouni, Laila Faddah, Azza M. Mohamad

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

Among famous medicinal plants with known antioxidant activity; black seed (Nigella sativa, NS) and garlic (Allium sativum) which have been used in traditional medicine. In recent years, rates of metabolic syndrome (MS) have been increasing globally. The present work was designed to study the potential protective effects of black seed and raw garlic homogenate against fructose-induced MS in rats and to assess the benefits gained from their combination. Fifty male albino Wistar rats were divided into 5 groups. A control group was allowed to feed on normal chow and drink tap water. MS group was fed the same diet plus 10% fructose in drinking water. Treated groups received NS or garlic either alone or in combination as oral supplements along with high fructose diet for 8 weeks. Results revealed that body weight, liver weight, fasting blood glucose, serum triglycerides (TG), total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels were significantly increased while high density lipoprotein cholesterol (HDL-C) and the activities of Lactate dehydrogenase (LDH), glucose -6-phosphate dehydrogenase (G-6-PHD) and catalase in liver tissues were significantly decreased in MS group compared to the control group. Administration of NS or garlic either alone or in combination significantly ameliorated all the abovementioned altered parameters. Treatment with both NS and garlic showed the utmost reduction in serum LDL-C and TG levels and could restore the activities of the studied enzymes in liver nearly to normal values. It was concluded that both NS and garlic were effective in attenuating multiple abnormalities of MS. Combination of these medicinal plants may have additional effectiveness in reducing serum TC, LDL-C and increasing HDL-C levels which could be a step in the prevention and management of MS.

Original languageEnglish
Pages (from-to)839-848
Number of pages10
JournalJournal of Oleo Science
Volume63
Issue number8
DOIs
Publication statusPublished - 1 Jan 2014

Fingerprint

Fructose
Cholesterol
Liver
LDL Cholesterol
Lipoproteins
Rats
Nutrition
HDL Cholesterol
Seed
Glucosephosphate Dehydrogenase
L-Lactate Dehydrogenase
Drinking Water
Catalase
Medicine
Blood Glucose
Triglycerides
Antioxidants
Glucose
Tissue
Water

Keywords

  • Dyslipidemia
  • Garlic
  • Metabolic syndrome
  • Nigella sativa
  • Rats

Cite this

Al-Rasheed, Nawal ; Al-Rasheed, Nouf ; Bassiouni, Yieldez ; Faddah, Laila ; Mohamad, Azza M. / Potential protective effects of Nigella sativaand allium sativum against fructose-induced metabolic syndrome in rats. In: Journal of Oleo Science. 2014 ; Vol. 63, No. 8. pp. 839-848.
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abstract = "Among famous medicinal plants with known antioxidant activity; black seed (Nigella sativa, NS) and garlic (Allium sativum) which have been used in traditional medicine. In recent years, rates of metabolic syndrome (MS) have been increasing globally. The present work was designed to study the potential protective effects of black seed and raw garlic homogenate against fructose-induced MS in rats and to assess the benefits gained from their combination. Fifty male albino Wistar rats were divided into 5 groups. A control group was allowed to feed on normal chow and drink tap water. MS group was fed the same diet plus 10{\%} fructose in drinking water. Treated groups received NS or garlic either alone or in combination as oral supplements along with high fructose diet for 8 weeks. Results revealed that body weight, liver weight, fasting blood glucose, serum triglycerides (TG), total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels were significantly increased while high density lipoprotein cholesterol (HDL-C) and the activities of Lactate dehydrogenase (LDH), glucose -6-phosphate dehydrogenase (G-6-PHD) and catalase in liver tissues were significantly decreased in MS group compared to the control group. Administration of NS or garlic either alone or in combination significantly ameliorated all the abovementioned altered parameters. Treatment with both NS and garlic showed the utmost reduction in serum LDL-C and TG levels and could restore the activities of the studied enzymes in liver nearly to normal values. It was concluded that both NS and garlic were effective in attenuating multiple abnormalities of MS. Combination of these medicinal plants may have additional effectiveness in reducing serum TC, LDL-C and increasing HDL-C levels which could be a step in the prevention and management of MS.",
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Potential protective effects of Nigella sativaand allium sativum against fructose-induced metabolic syndrome in rats. / Al-Rasheed, Nawal; Al-Rasheed, Nouf; Bassiouni, Yieldez; Faddah, Laila; Mohamad, Azza M.

In: Journal of Oleo Science, Vol. 63, No. 8, 01.01.2014, p. 839-848.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Potential protective effects of Nigella sativaand allium sativum against fructose-induced metabolic syndrome in rats

AU - Al-Rasheed, Nawal

AU - Al-Rasheed, Nouf

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AU - Faddah, Laila

AU - Mohamad, Azza M.

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AB - Among famous medicinal plants with known antioxidant activity; black seed (Nigella sativa, NS) and garlic (Allium sativum) which have been used in traditional medicine. In recent years, rates of metabolic syndrome (MS) have been increasing globally. The present work was designed to study the potential protective effects of black seed and raw garlic homogenate against fructose-induced MS in rats and to assess the benefits gained from their combination. Fifty male albino Wistar rats were divided into 5 groups. A control group was allowed to feed on normal chow and drink tap water. MS group was fed the same diet plus 10% fructose in drinking water. Treated groups received NS or garlic either alone or in combination as oral supplements along with high fructose diet for 8 weeks. Results revealed that body weight, liver weight, fasting blood glucose, serum triglycerides (TG), total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels were significantly increased while high density lipoprotein cholesterol (HDL-C) and the activities of Lactate dehydrogenase (LDH), glucose -6-phosphate dehydrogenase (G-6-PHD) and catalase in liver tissues were significantly decreased in MS group compared to the control group. Administration of NS or garlic either alone or in combination significantly ameliorated all the abovementioned altered parameters. Treatment with both NS and garlic showed the utmost reduction in serum LDL-C and TG levels and could restore the activities of the studied enzymes in liver nearly to normal values. It was concluded that both NS and garlic were effective in attenuating multiple abnormalities of MS. Combination of these medicinal plants may have additional effectiveness in reducing serum TC, LDL-C and increasing HDL-C levels which could be a step in the prevention and management of MS.

KW - Dyslipidemia

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