Potentiometric sensor for the determination of betaxolol hydrochloride in plasma and urine

Research output: Contribution to journalArticleResearchpeer-review

Abstract

A novel betaxolol ion-selective electrode is prepared, characterized, and used in biological fluids analysis. The electrode incorporates PVC membrane with betaxolol-tetraphenylborate (BT-TPB) ion pair complex with di-butyl phosphate (DBP) as a plasticizer. The calibration curve is linear in the range from 1.0×10−6 to 1.0×10−2 mol/L with a correlation coefficient of 0.997 and slope of 59.0 mV/decade, which is close to the Nernstian slope. Selectivity coefficients of BT related to a number of interfering cation, sugars and amino-acids were investigated. The influence of pH of the tested solutions on the formulation of the electrode is not as considerable since the electrode works correctly in the pH range 3.20-8.30. The electrode was successfully used for potentiometric determination of betaxolol hydrochloride both in pure solutions and in biological fluids.

Original languageEnglish
Article number61
Pages (from-to)332-336
Number of pages5
JournalInternational Journal of Pharmaceutical Sciences Review and Research
Volume41
Issue number2
Publication statusPublished - 1 Nov 2016

Fingerprint

Betaxolol
Electrodes
Urine
Tetraphenylborate
Ion-Selective Electrodes
Sugar Acids
Plasticizers
Polyvinyl Chloride
Calibration
Cations
Phosphates
Ions
Amino Acids
Membranes

Keywords

  • Betaxolol HCl
  • Membrane electrode
  • Potentiometry

Cite this

Alturiqi, A. S. (2016). Potentiometric sensor for the determination of betaxolol hydrochloride in plasma and urine. International Journal of Pharmaceutical Sciences Review and Research, 41(2), 332-336. [61].
Alturiqi, Amani S. / Potentiometric sensor for the determination of betaxolol hydrochloride in plasma and urine. In: International Journal of Pharmaceutical Sciences Review and Research. 2016 ; Vol. 41, No. 2. pp. 332-336.
@article{45be0b3ef5db4c49b2ea305bf509c368,
title = "Potentiometric sensor for the determination of betaxolol hydrochloride in plasma and urine",
abstract = "A novel betaxolol ion-selective electrode is prepared, characterized, and used in biological fluids analysis. The electrode incorporates PVC membrane with betaxolol-tetraphenylborate (BT-TPB) ion pair complex with di-butyl phosphate (DBP) as a plasticizer. The calibration curve is linear in the range from 1.0×10−6 to 1.0×10−2 mol/L with a correlation coefficient of 0.997 and slope of 59.0 mV/decade, which is close to the Nernstian slope. Selectivity coefficients of BT related to a number of interfering cation, sugars and amino-acids were investigated. The influence of pH of the tested solutions on the formulation of the electrode is not as considerable since the electrode works correctly in the pH range 3.20-8.30. The electrode was successfully used for potentiometric determination of betaxolol hydrochloride both in pure solutions and in biological fluids.",
keywords = "Betaxolol HCl, Membrane electrode, Potentiometry",
author = "Alturiqi, {Amani S.}",
year = "2016",
month = "11",
day = "1",
language = "English",
volume = "41",
pages = "332--336",
number = "2",

}

Alturiqi, AS 2016, 'Potentiometric sensor for the determination of betaxolol hydrochloride in plasma and urine', International Journal of Pharmaceutical Sciences Review and Research, vol. 41, no. 2, 61, pp. 332-336.

Potentiometric sensor for the determination of betaxolol hydrochloride in plasma and urine. / Alturiqi, Amani S.

In: International Journal of Pharmaceutical Sciences Review and Research, Vol. 41, No. 2, 61, 01.11.2016, p. 332-336.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Potentiometric sensor for the determination of betaxolol hydrochloride in plasma and urine

AU - Alturiqi, Amani S.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - A novel betaxolol ion-selective electrode is prepared, characterized, and used in biological fluids analysis. The electrode incorporates PVC membrane with betaxolol-tetraphenylborate (BT-TPB) ion pair complex with di-butyl phosphate (DBP) as a plasticizer. The calibration curve is linear in the range from 1.0×10−6 to 1.0×10−2 mol/L with a correlation coefficient of 0.997 and slope of 59.0 mV/decade, which is close to the Nernstian slope. Selectivity coefficients of BT related to a number of interfering cation, sugars and amino-acids were investigated. The influence of pH of the tested solutions on the formulation of the electrode is not as considerable since the electrode works correctly in the pH range 3.20-8.30. The electrode was successfully used for potentiometric determination of betaxolol hydrochloride both in pure solutions and in biological fluids.

AB - A novel betaxolol ion-selective electrode is prepared, characterized, and used in biological fluids analysis. The electrode incorporates PVC membrane with betaxolol-tetraphenylborate (BT-TPB) ion pair complex with di-butyl phosphate (DBP) as a plasticizer. The calibration curve is linear in the range from 1.0×10−6 to 1.0×10−2 mol/L with a correlation coefficient of 0.997 and slope of 59.0 mV/decade, which is close to the Nernstian slope. Selectivity coefficients of BT related to a number of interfering cation, sugars and amino-acids were investigated. The influence of pH of the tested solutions on the formulation of the electrode is not as considerable since the electrode works correctly in the pH range 3.20-8.30. The electrode was successfully used for potentiometric determination of betaxolol hydrochloride both in pure solutions and in biological fluids.

KW - Betaxolol HCl

KW - Membrane electrode

KW - Potentiometry

UR - http://www.scopus.com/inward/record.url?scp=85018204614&partnerID=8YFLogxK

M3 - Article

VL - 41

SP - 332

EP - 336

IS - 2

M1 - 61

ER -

Alturiqi AS. Potentiometric sensor for the determination of betaxolol hydrochloride in plasma and urine. International Journal of Pharmaceutical Sciences Review and Research. 2016 Nov 1;41(2):332-336. 61.