Preparation and evaluation of periodontal films based on polyelectrolyte complex formation

Abeer Ahmed Kassem, Fatma Ahmed Ismail, Viviane Fahim Naggar, Elsayed Aboulmagd

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Abstract

Local intra-pocket drug delivery devices can provide an effective concentration of the antimicrobial agent at the site of action with avoidance of undesirable side effects. This study explored the application of chitosan-alginate and chitosan-pectin polyelectrolyte complex (PEC) films as drug release regulators for tetracycline HCl (Tc) to treat periodontal pockets. Periodontal films with 1:1 Tc:PEC ratio were prepared using 1:1 chitosan (Ch) to sodium alginate (A) or 1:3 Ch to pectin (P). The scanning electron microscope showed acceptable film appearance and differential scanning calorimetry analysis confirmed complex formation. The in vitro release studies for both films showed a burst drug release, followed by prolonged release for 70 h. A prolonged antibacterial activity of both films against Staphylococcus aureus ATCC 6538 was observed over a period of 21 days. Aging studies indicated that the five months storage period in freezer did not significantly influence the drug release profile or the antibacterial activity of both films. Clinical evaluation showed a significant reduction in pocket depth (p < 0.0001) to their normal values (≤3 mm). PEC films could be exploited as a prolonged drug release devices for treatment of periodontal pockets.

Original languageEnglish
Pages (from-to)297-305
Number of pages9
JournalPharmaceutical Development and Technology
Volume20
Issue number3
DOIs
Publication statusPublished - 1 May 2015

Fingerprint

Periodontal Pocket
Equipment and Supplies
Differential Scanning Calorimetry
Anti-Infective Agents
Tetracycline
Staphylococcus aureus
Reference Values
Electrons
Drug Liberation
Polyelectrolytes
Pharmaceutical Preparations
alginic acid
pectin

Keywords

  • Chitosan-alginate
  • Chitosan-pectin
  • Clinical studies
  • Release behavior
  • Tetracycline HCl

Cite this

Kassem, Abeer Ahmed ; Ismail, Fatma Ahmed ; Naggar, Viviane Fahim ; Aboulmagd, Elsayed. / Preparation and evaluation of periodontal films based on polyelectrolyte complex formation. In: Pharmaceutical Development and Technology. 2015 ; Vol. 20, No. 3. pp. 297-305.
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Preparation and evaluation of periodontal films based on polyelectrolyte complex formation. / Kassem, Abeer Ahmed; Ismail, Fatma Ahmed; Naggar, Viviane Fahim; Aboulmagd, Elsayed.

In: Pharmaceutical Development and Technology, Vol. 20, No. 3, 01.05.2015, p. 297-305.

Research output: Contribution to journalArticleResearchpeer-review

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