Promising method in formulating ocular bio-adhesive inserts of ciprofloxacin hydrochloride combination with xanthan gum and carbopol

Samar Z. Al-Shawwa, Aiman A. Obaidat, Alsayed A. Sallam, Mutaz S. Salem

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Ciprofloxacin hydrochloride (CFX-HCl) is an antibiotic used to treat bacterial infections in different parts of the body. This study outlines the development and characterization of a controlled-release CFX-HCl drug delivery system. The study utilized propylene glycol (PG), carbopol 934P (C-934), and xanthan gum (XG) micro-encapsulated via the spray-drying method. According to British Pharmacopoeia, the drug delivery systems were sterilized with the assistance of gamma radiation. Investigation of the spray-dried powder was carried out by scanning electron microscopy (SEM). Stability studies were also performed. The systems displayed sustained and controlled release of CFX-HCl in in vitro studies over a prolonged period. The shelf-life of the product containing PG was determined to be greater than two years. Such systems, which are physically and chemically stable, may yield huge therapeutic benefits in the management of conjunctivitis and corneal ulceration.

Original languageEnglish
Pages (from-to)1607-1617
Number of pages11
JournalLatin American Journal of Pharmacy
Volume35
Issue number7
Publication statusPublished - 1 Jan 2016

Fingerprint

Ciprofloxacin
Adhesives
Propylene Glycol
Drug Delivery Systems
Pharmacopoeias
Conjunctivitis
Gamma Rays
Human Body
Bacterial Infections
Electron Scanning Microscopy
Powders
Anti-Bacterial Agents
xanthan gum
carboxypolymethylene
Therapeutics

Keywords

  • Carbopol 934P
  • Ciprofloxacin hydrochloride
  • Controlled release drug delivery
  • Gel-forming systems
  • Propylene glycol
  • Xanthan gum

Cite this

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title = "Promising method in formulating ocular bio-adhesive inserts of ciprofloxacin hydrochloride combination with xanthan gum and carbopol",
abstract = "Ciprofloxacin hydrochloride (CFX-HCl) is an antibiotic used to treat bacterial infections in different parts of the body. This study outlines the development and characterization of a controlled-release CFX-HCl drug delivery system. The study utilized propylene glycol (PG), carbopol 934P (C-934), and xanthan gum (XG) micro-encapsulated via the spray-drying method. According to British Pharmacopoeia, the drug delivery systems were sterilized with the assistance of gamma radiation. Investigation of the spray-dried powder was carried out by scanning electron microscopy (SEM). Stability studies were also performed. The systems displayed sustained and controlled release of CFX-HCl in in vitro studies over a prolonged period. The shelf-life of the product containing PG was determined to be greater than two years. Such systems, which are physically and chemically stable, may yield huge therapeutic benefits in the management of conjunctivitis and corneal ulceration.",
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Promising method in formulating ocular bio-adhesive inserts of ciprofloxacin hydrochloride combination with xanthan gum and carbopol. / Al-Shawwa, Samar Z.; Obaidat, Aiman A.; Sallam, Alsayed A.; Salem, Mutaz S.

In: Latin American Journal of Pharmacy, Vol. 35, No. 7, 01.01.2016, p. 1607-1617.

Research output: Contribution to journalArticleResearchpeer-review

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