Prophylactic effect of artemether on human schistosomiasis mansoni among Egyptian children

A randomized controlled trial

Hala Elmorshedy, Marcel Tanner, Robert N. Bergquist, Soraya Sharaf, Rashida Barakat

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

A double-blind, randomized controlled trial was conducted in an endemic focus for Schistosoma mansoni in Kafr El-Sheikh Governorate, Northern Nile Delta, Egypt, to evaluate the prophylactic effect of artemether (ART) given in conjunction with praziquantel (PZQ). The study encompassed 913 primary school children randomly assigned to two treatment groups PZQ/ART and PZQ/ART-placebo. At baseline, both groups received 40 mg/kg body weight of PZQ twice four weeks apart, after which one group received 6 mg/kg body weight of ART every 3 weeks in 5 cycles during the transmission season and the other group received ART-placebo. At the end of the study, prevalence of infection among the PZQ/ART was approximately half that of the PZQ/ART-placebo group, i.e. 6.7% versus 11.6%, and incidence of new infections for the PZQ/ART was 2.7% versus 6.5% for the PZQ/ART-placebo. In conclusion, PZQ/ART combined therapy might be considered as an adjunct measure against human schistosomiasis, by specifically reducing transmission and therefore contribute to disease elimination.

Original languageEnglish
Pages (from-to)52-58
Number of pages7
JournalActa Tropica
Volume158
DOIs
Publication statusPublished - 1 Jun 2016

Fingerprint

praziquantel
Schistosomiasis mansoni
Praziquantel
Randomized Controlled Trials
placebos
Placebos
Body Weight
artemether
schistosomiasis mansoni
Disease Eradication
schistosomiasis
elementary schools
body weight
school children
Schistosoma mansoni
Egypt
Schistosomiasis
infection
Infection
Cross-Sectional Studies

Keywords

  • Artemether
  • Egypt
  • Praziquantel
  • Prophylaxis
  • Randomized control trial
  • Schistosoma mansoni

Cite this

Elmorshedy, Hala ; Tanner, Marcel ; Bergquist, Robert N. ; Sharaf, Soraya ; Barakat, Rashida. / Prophylactic effect of artemether on human schistosomiasis mansoni among Egyptian children : A randomized controlled trial. In: Acta Tropica. 2016 ; Vol. 158. pp. 52-58.
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abstract = "A double-blind, randomized controlled trial was conducted in an endemic focus for Schistosoma mansoni in Kafr El-Sheikh Governorate, Northern Nile Delta, Egypt, to evaluate the prophylactic effect of artemether (ART) given in conjunction with praziquantel (PZQ). The study encompassed 913 primary school children randomly assigned to two treatment groups PZQ/ART and PZQ/ART-placebo. At baseline, both groups received 40 mg/kg body weight of PZQ twice four weeks apart, after which one group received 6 mg/kg body weight of ART every 3 weeks in 5 cycles during the transmission season and the other group received ART-placebo. At the end of the study, prevalence of infection among the PZQ/ART was approximately half that of the PZQ/ART-placebo group, i.e. 6.7{\%} versus 11.6{\%}, and incidence of new infections for the PZQ/ART was 2.7{\%} versus 6.5{\%} for the PZQ/ART-placebo. In conclusion, PZQ/ART combined therapy might be considered as an adjunct measure against human schistosomiasis, by specifically reducing transmission and therefore contribute to disease elimination.",
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Prophylactic effect of artemether on human schistosomiasis mansoni among Egyptian children : A randomized controlled trial. / Elmorshedy, Hala; Tanner, Marcel; Bergquist, Robert N.; Sharaf, Soraya; Barakat, Rashida.

In: Acta Tropica, Vol. 158, 01.06.2016, p. 52-58.

Research output: Contribution to journalArticleResearchpeer-review

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