Protective potential of grape seed proanthocyandins extract against glivec (Imatinib mesylate) induced liver toxicity and oxidative stress in male rats

Nawal M. Al-Rasheed, Thanaa A. El-Masry, Ehab Tousson, Hanan M. Hassan, Areej Al-Ghadeer

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: Glivec (Imatinib mesylate) an antineoplastic chemotherapeutic agent used in the treatment of many types of cancer. The current study examines the hepatoprotective potential of grape seed proanthocyandins extract (GSPE) against Glivec induced oxidative stress and toxicity in male albino rats. Materials and Methods: A total of 40 male albino rats were equally divided into four groups; group 1 was control, group 2 was GSPE group (rats received orally GSPE by stomach tube (50 mg/kg BW/twice a week) for four week), group 3 was Glivec group (rats were injected intraperitoneally with Glivec (1 mg/kg B W/twice a week) for four weeks) and group 4 was rats treated with GSPE plus Glivec for four weeks. Results: LD50 was calculated for Glivec in rats (estimated at 598 mg/kg), presenting confidence limits between 588 and 612 mg/kg body weight. A significant increase in the liver TBARS and aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and γ- glutamyltransferase (GGT) activities in Glivec group when compared with the control group. On the other hand; a significant decrease in the serum albumin, globulin, total protein, liver superoxide dismutase activity (SOD), catalase (CAT), glutathione S-trasferase (GST) and reduced glutathione (GSH) levels in Glivec group when compared with the control group. Administration of GSPE with Glivec caused a protective and ameliorative effect against Glivec induced liver toxicity. Conclusions: Treatment with GSPE has a promising role for ameliorating the oxidative stress and hepatic injury induced by Glivec.

Original languageEnglish
Article numberARRB.37766
JournalAnnual Research and Review in Biology
Volume20
Issue number6
DOIs
Publication statusPublished - 13 Dec 2017

Fingerprint

Grape Seed Extract
grape seed extract
Oxidative stress
hepatotoxicity
Liver
Toxicity
Rats
Oxidative Stress
oxidative stress
rats
albino
glutathione
liver protein
liver
antineoplastic agents
serum albumin
lethal dose 50
alanine transaminase
globulins
thiobarbituric acid-reactive substances

Keywords

  • Chemotherapy
  • Glivec
  • GSPE
  • Imatinib mesylate
  • Liver
  • Oxidative stress

Cite this

@article{9b7b593a2f7140df95ee5cf8b2709846,
title = "Protective potential of grape seed proanthocyandins extract against glivec (Imatinib mesylate) induced liver toxicity and oxidative stress in male rats",
abstract = "Objectives: Glivec (Imatinib mesylate) an antineoplastic chemotherapeutic agent used in the treatment of many types of cancer. The current study examines the hepatoprotective potential of grape seed proanthocyandins extract (GSPE) against Glivec induced oxidative stress and toxicity in male albino rats. Materials and Methods: A total of 40 male albino rats were equally divided into four groups; group 1 was control, group 2 was GSPE group (rats received orally GSPE by stomach tube (50 mg/kg BW/twice a week) for four week), group 3 was Glivec group (rats were injected intraperitoneally with Glivec (1 mg/kg B W/twice a week) for four weeks) and group 4 was rats treated with GSPE plus Glivec for four weeks. Results: LD50 was calculated for Glivec in rats (estimated at 598 mg/kg), presenting confidence limits between 588 and 612 mg/kg body weight. A significant increase in the liver TBARS and aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and γ- glutamyltransferase (GGT) activities in Glivec group when compared with the control group. On the other hand; a significant decrease in the serum albumin, globulin, total protein, liver superoxide dismutase activity (SOD), catalase (CAT), glutathione S-trasferase (GST) and reduced glutathione (GSH) levels in Glivec group when compared with the control group. Administration of GSPE with Glivec caused a protective and ameliorative effect against Glivec induced liver toxicity. Conclusions: Treatment with GSPE has a promising role for ameliorating the oxidative stress and hepatic injury induced by Glivec.",
keywords = "Chemotherapy, Glivec, GSPE, Imatinib mesylate, Liver, Oxidative stress",
author = "Al-Rasheed, {Nawal M.} and El-Masry, {Thanaa A.} and Ehab Tousson and Hassan, {Hanan M.} and Areej Al-Ghadeer",
year = "2017",
month = "12",
day = "13",
doi = "10.9734/ARRB/2017/37766",
language = "English",
volume = "20",
journal = "Annual Research and Review in Biology",
issn = "2347-565X",
publisher = "SCIENCEDOMAIN international",
number = "6",

}

Protective potential of grape seed proanthocyandins extract against glivec (Imatinib mesylate) induced liver toxicity and oxidative stress in male rats. / Al-Rasheed, Nawal M.; El-Masry, Thanaa A.; Tousson, Ehab; Hassan, Hanan M.; Al-Ghadeer, Areej.

In: Annual Research and Review in Biology, Vol. 20, No. 6, ARRB.37766, 13.12.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Protective potential of grape seed proanthocyandins extract against glivec (Imatinib mesylate) induced liver toxicity and oxidative stress in male rats

AU - Al-Rasheed, Nawal M.

AU - El-Masry, Thanaa A.

AU - Tousson, Ehab

AU - Hassan, Hanan M.

AU - Al-Ghadeer, Areej

PY - 2017/12/13

Y1 - 2017/12/13

N2 - Objectives: Glivec (Imatinib mesylate) an antineoplastic chemotherapeutic agent used in the treatment of many types of cancer. The current study examines the hepatoprotective potential of grape seed proanthocyandins extract (GSPE) against Glivec induced oxidative stress and toxicity in male albino rats. Materials and Methods: A total of 40 male albino rats were equally divided into four groups; group 1 was control, group 2 was GSPE group (rats received orally GSPE by stomach tube (50 mg/kg BW/twice a week) for four week), group 3 was Glivec group (rats were injected intraperitoneally with Glivec (1 mg/kg B W/twice a week) for four weeks) and group 4 was rats treated with GSPE plus Glivec for four weeks. Results: LD50 was calculated for Glivec in rats (estimated at 598 mg/kg), presenting confidence limits between 588 and 612 mg/kg body weight. A significant increase in the liver TBARS and aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and γ- glutamyltransferase (GGT) activities in Glivec group when compared with the control group. On the other hand; a significant decrease in the serum albumin, globulin, total protein, liver superoxide dismutase activity (SOD), catalase (CAT), glutathione S-trasferase (GST) and reduced glutathione (GSH) levels in Glivec group when compared with the control group. Administration of GSPE with Glivec caused a protective and ameliorative effect against Glivec induced liver toxicity. Conclusions: Treatment with GSPE has a promising role for ameliorating the oxidative stress and hepatic injury induced by Glivec.

AB - Objectives: Glivec (Imatinib mesylate) an antineoplastic chemotherapeutic agent used in the treatment of many types of cancer. The current study examines the hepatoprotective potential of grape seed proanthocyandins extract (GSPE) against Glivec induced oxidative stress and toxicity in male albino rats. Materials and Methods: A total of 40 male albino rats were equally divided into four groups; group 1 was control, group 2 was GSPE group (rats received orally GSPE by stomach tube (50 mg/kg BW/twice a week) for four week), group 3 was Glivec group (rats were injected intraperitoneally with Glivec (1 mg/kg B W/twice a week) for four weeks) and group 4 was rats treated with GSPE plus Glivec for four weeks. Results: LD50 was calculated for Glivec in rats (estimated at 598 mg/kg), presenting confidence limits between 588 and 612 mg/kg body weight. A significant increase in the liver TBARS and aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and γ- glutamyltransferase (GGT) activities in Glivec group when compared with the control group. On the other hand; a significant decrease in the serum albumin, globulin, total protein, liver superoxide dismutase activity (SOD), catalase (CAT), glutathione S-trasferase (GST) and reduced glutathione (GSH) levels in Glivec group when compared with the control group. Administration of GSPE with Glivec caused a protective and ameliorative effect against Glivec induced liver toxicity. Conclusions: Treatment with GSPE has a promising role for ameliorating the oxidative stress and hepatic injury induced by Glivec.

KW - Chemotherapy

KW - Glivec

KW - GSPE

KW - Imatinib mesylate

KW - Liver

KW - Oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=85038408041&partnerID=8YFLogxK

U2 - 10.9734/ARRB/2017/37766

DO - 10.9734/ARRB/2017/37766

M3 - Article

AN - SCOPUS:85038408041

VL - 20

JO - Annual Research and Review in Biology

JF - Annual Research and Review in Biology

SN - 2347-565X

IS - 6

M1 - ARRB.37766

ER -