Quantitative analysis of desvenlafaxine HCl by ion selective electrode

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The construction and electrochemical response characteristics of a poly vinyl chloride (PVC) membrane selective electrode for the determination of desvenlafaxine HCl (DVN) are described. The electrode incorporates PVC membrane with desvenlafaxine-silicomolybdate (DVN-SMA) ion pair complex with dioctylphthalate (DOP) as a plasticizer. The influence of the electrode composition, conditioning time of the electrode and pH of the test solution, on the electrode performance were investigated. The drug electrode showed Nernstian response in the concentration range from 1.0 × 10-5 M to 1.0 × 10-2 M with slope of 58.0 mV decade-1, and was found to be very precise and usable within the pH range 4 –8.5. The electrode showed good selectivity towards DVN with respect to some inorganic and organic compounds. The electrode was successfully used for potentiometric determination of DVN both in pure solutions, urine and in pharmaceutical preparations.

Original languageEnglish
Article number18
Pages (from-to)75-79
Number of pages5
JournalInternational Journal of Pharmaceutical Sciences Review and Research
Volume40
Issue number2
Publication statusPublished - 1 Sep 2016

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Ion-Selective Electrodes
Electrodes
Vinyl Chloride
Plasticizers
Membranes
Desvenlafaxine Succinate
Pharmaceutical Preparations
Urine
Ions

Keywords

  • Desvenlafaxine hydrochloride (DVN)
  • Ion-selective electrode
  • Potentiometry

Cite this

Alturiqi, A. S. (2016). Quantitative analysis of desvenlafaxine HCl by ion selective electrode. International Journal of Pharmaceutical Sciences Review and Research, 40(2), 75-79. [18].
Alturiqi, Amani S. / Quantitative analysis of desvenlafaxine HCl by ion selective electrode. In: International Journal of Pharmaceutical Sciences Review and Research. 2016 ; Vol. 40, No. 2. pp. 75-79.
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Alturiqi, AS 2016, 'Quantitative analysis of desvenlafaxine HCl by ion selective electrode', International Journal of Pharmaceutical Sciences Review and Research, vol. 40, no. 2, 18, pp. 75-79.

Quantitative analysis of desvenlafaxine HCl by ion selective electrode. / Alturiqi, Amani S.

In: International Journal of Pharmaceutical Sciences Review and Research, Vol. 40, No. 2, 18, 01.09.2016, p. 75-79.

Research output: Contribution to journalArticleResearchpeer-review

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N2 - The construction and electrochemical response characteristics of a poly vinyl chloride (PVC) membrane selective electrode for the determination of desvenlafaxine HCl (DVN) are described. The electrode incorporates PVC membrane with desvenlafaxine-silicomolybdate (DVN-SMA) ion pair complex with dioctylphthalate (DOP) as a plasticizer. The influence of the electrode composition, conditioning time of the electrode and pH of the test solution, on the electrode performance were investigated. The drug electrode showed Nernstian response in the concentration range from 1.0 × 10-5 M to 1.0 × 10-2 M with slope of 58.0 mV decade-1, and was found to be very precise and usable within the pH range 4 –8.5. The electrode showed good selectivity towards DVN with respect to some inorganic and organic compounds. The electrode was successfully used for potentiometric determination of DVN both in pure solutions, urine and in pharmaceutical preparations.

AB - The construction and electrochemical response characteristics of a poly vinyl chloride (PVC) membrane selective electrode for the determination of desvenlafaxine HCl (DVN) are described. The electrode incorporates PVC membrane with desvenlafaxine-silicomolybdate (DVN-SMA) ion pair complex with dioctylphthalate (DOP) as a plasticizer. The influence of the electrode composition, conditioning time of the electrode and pH of the test solution, on the electrode performance were investigated. The drug electrode showed Nernstian response in the concentration range from 1.0 × 10-5 M to 1.0 × 10-2 M with slope of 58.0 mV decade-1, and was found to be very precise and usable within the pH range 4 –8.5. The electrode showed good selectivity towards DVN with respect to some inorganic and organic compounds. The electrode was successfully used for potentiometric determination of DVN both in pure solutions, urine and in pharmaceutical preparations.

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Alturiqi AS. Quantitative analysis of desvenlafaxine HCl by ion selective electrode. International Journal of Pharmaceutical Sciences Review and Research. 2016 Sep 1;40(2):75-79. 18.