Recurrence of urinary tract infections and development of urinary-specific antibiogram for kidney transplant recipients

Ghazwa B. Korayem, Tirdad T. Zangeneh, Kathryn R. Matthias

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

Objectives: Urinary tract infection (UTI) recurrence and antimicrobial resistance remain a common problem in kidney transplant recipients. Whilst the use of annual institutional antibiograms may help guide appropriate empirical antibiotic selection, these non-disease specific antibiograms do not always account for patient-specific risk factors or disease-specific resistance patterns. This study determined the frequency of UTI recurrence during the first year after kidney transplantation as well as differences in antimicrobial susceptibility between an institutional antibiogram and the disease-specific antibiogram for patients following kidney transplantation. Methods: In this study, adult patients with at least one UTI during an inpatient admission within 1 year post kidney transplantation were evaluated. A disease-specific antibiogram for UTIs in kidney transplant recipients was prepared based on culture results and was compared with the annual institutional antibiograms. Results: Of 299 kidney transplants performed during the study period, 66 subjects meet the study inclusion criteria, of whom 47% had two or more UTIs within the first year after kidney transplant. In comparison with the institutional antibiogram, Escherichia coli isolated from urine samples from kidney transplant recipients were significantly more resistant to trimethoprim/sulfamethoxazole, ceftriaxone, cefepime, ciprofloxacin and gentamicin (P < 0.0001). Conclusions: Multiple UTIs are common in kidney transplant recipients during the first year post-transplantation. E. coli urinary isolates were significantly more resistant to multiple antibiotic drug classes in this patient population compared with the general hospital population. Antimicrobial stewardship programmes at transplant centres should consider producing disease-specific antibiograms specifically for transplant recipients to improve empirical antibiotic selection guidance.

Original languageEnglish
Pages (from-to)119-123
Number of pages5
JournalJournal of Global Antimicrobial Resistance
Volume12
DOIs
Publication statusPublished - 1 Mar 2018

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Microbial Sensitivity Tests
Urinary Tract Infections
Kidney
Recurrence
Kidney Transplantation
Anti-Bacterial Agents
Transplants
Escherichia coli
Disease Resistance
Ceftriaxone
Transplant Recipients
Sulfamethoxazole Drug Combination Trimethoprim
Ciprofloxacin
Gentamicins
General Hospitals
Population
Inpatients
Transplantation
Urine
Pharmaceutical Preparations

Keywords

  • Kidney transplant
  • Recurrence
  • Resistance
  • Urinary tract infection
  • Urinary-specific antibiogram

Cite this

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title = "Recurrence of urinary tract infections and development of urinary-specific antibiogram for kidney transplant recipients",
abstract = "Objectives: Urinary tract infection (UTI) recurrence and antimicrobial resistance remain a common problem in kidney transplant recipients. Whilst the use of annual institutional antibiograms may help guide appropriate empirical antibiotic selection, these non-disease specific antibiograms do not always account for patient-specific risk factors or disease-specific resistance patterns. This study determined the frequency of UTI recurrence during the first year after kidney transplantation as well as differences in antimicrobial susceptibility between an institutional antibiogram and the disease-specific antibiogram for patients following kidney transplantation. Methods: In this study, adult patients with at least one UTI during an inpatient admission within 1 year post kidney transplantation were evaluated. A disease-specific antibiogram for UTIs in kidney transplant recipients was prepared based on culture results and was compared with the annual institutional antibiograms. Results: Of 299 kidney transplants performed during the study period, 66 subjects meet the study inclusion criteria, of whom 47{\%} had two or more UTIs within the first year after kidney transplant. In comparison with the institutional antibiogram, Escherichia coli isolated from urine samples from kidney transplant recipients were significantly more resistant to trimethoprim/sulfamethoxazole, ceftriaxone, cefepime, ciprofloxacin and gentamicin (P < 0.0001). Conclusions: Multiple UTIs are common in kidney transplant recipients during the first year post-transplantation. E. coli urinary isolates were significantly more resistant to multiple antibiotic drug classes in this patient population compared with the general hospital population. Antimicrobial stewardship programmes at transplant centres should consider producing disease-specific antibiograms specifically for transplant recipients to improve empirical antibiotic selection guidance.",
keywords = "Kidney transplant, Recurrence, Resistance, Urinary tract infection, Urinary-specific antibiogram",
author = "Korayem, {Ghazwa B.} and Zangeneh, {Tirdad T.} and Matthias, {Kathryn R.}",
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Recurrence of urinary tract infections and development of urinary-specific antibiogram for kidney transplant recipients. / Korayem, Ghazwa B.; Zangeneh, Tirdad T.; Matthias, Kathryn R.

In: Journal of Global Antimicrobial Resistance, Vol. 12, 01.03.2018, p. 119-123.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Recurrence of urinary tract infections and development of urinary-specific antibiogram for kidney transplant recipients

AU - Korayem, Ghazwa B.

AU - Zangeneh, Tirdad T.

AU - Matthias, Kathryn R.

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Objectives: Urinary tract infection (UTI) recurrence and antimicrobial resistance remain a common problem in kidney transplant recipients. Whilst the use of annual institutional antibiograms may help guide appropriate empirical antibiotic selection, these non-disease specific antibiograms do not always account for patient-specific risk factors or disease-specific resistance patterns. This study determined the frequency of UTI recurrence during the first year after kidney transplantation as well as differences in antimicrobial susceptibility between an institutional antibiogram and the disease-specific antibiogram for patients following kidney transplantation. Methods: In this study, adult patients with at least one UTI during an inpatient admission within 1 year post kidney transplantation were evaluated. A disease-specific antibiogram for UTIs in kidney transplant recipients was prepared based on culture results and was compared with the annual institutional antibiograms. Results: Of 299 kidney transplants performed during the study period, 66 subjects meet the study inclusion criteria, of whom 47% had two or more UTIs within the first year after kidney transplant. In comparison with the institutional antibiogram, Escherichia coli isolated from urine samples from kidney transplant recipients were significantly more resistant to trimethoprim/sulfamethoxazole, ceftriaxone, cefepime, ciprofloxacin and gentamicin (P < 0.0001). Conclusions: Multiple UTIs are common in kidney transplant recipients during the first year post-transplantation. E. coli urinary isolates were significantly more resistant to multiple antibiotic drug classes in this patient population compared with the general hospital population. Antimicrobial stewardship programmes at transplant centres should consider producing disease-specific antibiograms specifically for transplant recipients to improve empirical antibiotic selection guidance.

AB - Objectives: Urinary tract infection (UTI) recurrence and antimicrobial resistance remain a common problem in kidney transplant recipients. Whilst the use of annual institutional antibiograms may help guide appropriate empirical antibiotic selection, these non-disease specific antibiograms do not always account for patient-specific risk factors or disease-specific resistance patterns. This study determined the frequency of UTI recurrence during the first year after kidney transplantation as well as differences in antimicrobial susceptibility between an institutional antibiogram and the disease-specific antibiogram for patients following kidney transplantation. Methods: In this study, adult patients with at least one UTI during an inpatient admission within 1 year post kidney transplantation were evaluated. A disease-specific antibiogram for UTIs in kidney transplant recipients was prepared based on culture results and was compared with the annual institutional antibiograms. Results: Of 299 kidney transplants performed during the study period, 66 subjects meet the study inclusion criteria, of whom 47% had two or more UTIs within the first year after kidney transplant. In comparison with the institutional antibiogram, Escherichia coli isolated from urine samples from kidney transplant recipients were significantly more resistant to trimethoprim/sulfamethoxazole, ceftriaxone, cefepime, ciprofloxacin and gentamicin (P < 0.0001). Conclusions: Multiple UTIs are common in kidney transplant recipients during the first year post-transplantation. E. coli urinary isolates were significantly more resistant to multiple antibiotic drug classes in this patient population compared with the general hospital population. Antimicrobial stewardship programmes at transplant centres should consider producing disease-specific antibiograms specifically for transplant recipients to improve empirical antibiotic selection guidance.

KW - Kidney transplant

KW - Recurrence

KW - Resistance

KW - Urinary tract infection

KW - Urinary-specific antibiogram

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U2 - 10.1016/j.jgar.2017.08.009

DO - 10.1016/j.jgar.2017.08.009

M3 - Article

VL - 12

SP - 119

EP - 123

JO - Journal of Global Antimicrobial Resistance

JF - Journal of Global Antimicrobial Resistance

SN - 2213-7165

ER -