Role of carnosine and melatonin in ameliorating cardiotoxicity of titanium dioxide nanoparticles in the rats

Nouf Al-Rasheed, Laila Faddah, Hanan Ibrahim, Azza M. Mohamed, Nawal Al-Rasheed, Nayira Abdelbaky

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

The aim of this work was to study the possible cardiotoxicity of two different doses of 50 nm nano titanium dioxide (n-TiO2) and the possible modulating effects of the use of two natural antioxidants carnosine and melatonin. The results showed that TiO2-NPs produced deleterious effects on rat cardiac tissue as confirmed by the increased levels of serum myoglobin, troponin-T and CK-MB. Increased levels of serum Inflammatory markers represented by the tumor necrosis factor alpha (TNF-α) and Interleukin-6 (IL-6) was also noticed. Caspase3 and IGg were elevated compared to the control group in a dose dependant manner. treatment of the rats with Carnosine or melatonin. along with TiO2-NPs administration significantly improved most of the elevated biochemical markers. It was concluded that the use of Carnosine or melatonin could play a beneficial role against deleterious effects of TiO2-NPs.

Original languageEnglish
Pages (from-to)577-586
Number of pages10
JournalBrazilian Archives of Biology and Technology
Volume58
Issue number4
DOIs
Publication statusPublished - 1 Jan 2015

Fingerprint

Carnosine
Melatonin
Nanoparticles
Biomarkers
Troponin T
Myoglobin
Interleukin-6
Tumor Necrosis Factor-alpha
Antioxidants
Control Groups
Serum
titanium dioxide
Cardiotoxicity

Keywords

  • Cardiotoxicity
  • Carnosine
  • Melatonin
  • Titanium dioxide nanoparticles

Cite this

Al-Rasheed, Nouf ; Faddah, Laila ; Ibrahim, Hanan ; Mohamed, Azza M. ; Al-Rasheed, Nawal ; Abdelbaky, Nayira. / Role of carnosine and melatonin in ameliorating cardiotoxicity of titanium dioxide nanoparticles in the rats. In: Brazilian Archives of Biology and Technology. 2015 ; Vol. 58, No. 4. pp. 577-586.
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abstract = "The aim of this work was to study the possible cardiotoxicity of two different doses of 50 nm nano titanium dioxide (n-TiO2) and the possible modulating effects of the use of two natural antioxidants carnosine and melatonin. The results showed that TiO2-NPs produced deleterious effects on rat cardiac tissue as confirmed by the increased levels of serum myoglobin, troponin-T and CK-MB. Increased levels of serum Inflammatory markers represented by the tumor necrosis factor alpha (TNF-α) and Interleukin-6 (IL-6) was also noticed. Caspase3 and IGg were elevated compared to the control group in a dose dependant manner. treatment of the rats with Carnosine or melatonin. along with TiO2-NPs administration significantly improved most of the elevated biochemical markers. It was concluded that the use of Carnosine or melatonin could play a beneficial role against deleterious effects of TiO2-NPs.",
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Role of carnosine and melatonin in ameliorating cardiotoxicity of titanium dioxide nanoparticles in the rats. / Al-Rasheed, Nouf; Faddah, Laila; Ibrahim, Hanan; Mohamed, Azza M.; Al-Rasheed, Nawal; Abdelbaky, Nayira.

In: Brazilian Archives of Biology and Technology, Vol. 58, No. 4, 01.01.2015, p. 577-586.

Research output: Contribution to journalArticleResearchpeer-review

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