Abstract
Seven types of complexes were obtained when penicillin G potassium (pin) was reacted with transition and non-transition metal ions in methanol/distilled water mixed solvent. Magnetic susceptibilities and ESR spectra (CuII complex) of powdered samples indicated that the monomeric form of the complexes in the solid state, and the paramagnetic nature of the CuII, Ni II, MnII, CrIII, CoII, and Fe III complexes is attributable to the octahedral ligitional behavior of the potassium G penicillinate ligand. The antibacterial activity of the metal complexes were tested against some kind of bacteria and fungi strains and compared with penicillin G potassium activity. The possible mechanism of antibacterial action is discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 143-156 |
| Number of pages | 14 |
| Journal | Russian Journal of General Chemistry |
| Volume | 84 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Jan 2014 |
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Spectroscopic and thermal investigations of transition and non-transition metal complexes of penicillin G as potential biological active species. / Refat, Moamen S.; Al-Saif, Foziah A.
In: Russian Journal of General Chemistry, Vol. 84, No. 1, 01.01.2014, p. 143-156.Research output: Contribution to journal › Article
TY - JOUR
T1 - Spectroscopic and thermal investigations of transition and non-transition metal complexes of penicillin G as potential biological active species
AU - Refat, Moamen S.
AU - Al-Saif, Foziah A.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Seven types of complexes were obtained when penicillin G potassium (pin) was reacted with transition and non-transition metal ions in methanol/distilled water mixed solvent. Magnetic susceptibilities and ESR spectra (CuII complex) of powdered samples indicated that the monomeric form of the complexes in the solid state, and the paramagnetic nature of the CuII, Ni II, MnII, CrIII, CoII, and Fe III complexes is attributable to the octahedral ligitional behavior of the potassium G penicillinate ligand. The antibacterial activity of the metal complexes were tested against some kind of bacteria and fungi strains and compared with penicillin G potassium activity. The possible mechanism of antibacterial action is discussed.
AB - Seven types of complexes were obtained when penicillin G potassium (pin) was reacted with transition and non-transition metal ions in methanol/distilled water mixed solvent. Magnetic susceptibilities and ESR spectra (CuII complex) of powdered samples indicated that the monomeric form of the complexes in the solid state, and the paramagnetic nature of the CuII, Ni II, MnII, CrIII, CoII, and Fe III complexes is attributable to the octahedral ligitional behavior of the potassium G penicillinate ligand. The antibacterial activity of the metal complexes were tested against some kind of bacteria and fungi strains and compared with penicillin G potassium activity. The possible mechanism of antibacterial action is discussed.
UR - http://www.scopus.com/inward/record.url?scp=84894575504&partnerID=8YFLogxK
U2 - 10.1134/S1070363214010228
DO - 10.1134/S1070363214010228
M3 - Article
AN - SCOPUS:84894575504
VL - 84
SP - 143
EP - 156
JO - Russian Journal of General Chemistry
JF - Russian Journal of General Chemistry
SN - 1070-3632
IS - 1
ER -