Spectroscopic and thermal investigations of transition and non-transition metal complexes of penicillin G as potential biological active species

Moamen S. Refat, Foziah A. Al-Saif

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Abstract

Seven types of complexes were obtained when penicillin G potassium (pin) was reacted with transition and non-transition metal ions in methanol/distilled water mixed solvent. Magnetic susceptibilities and ESR spectra (CuII complex) of powdered samples indicated that the monomeric form of the complexes in the solid state, and the paramagnetic nature of the CuII, Ni II, MnII, CrIII, CoII, and Fe III complexes is attributable to the octahedral ligitional behavior of the potassium G penicillinate ligand. The antibacterial activity of the metal complexes were tested against some kind of bacteria and fungi strains and compared with penicillin G potassium activity. The possible mechanism of antibacterial action is discussed.

Original languageEnglish
Pages (from-to)143-156
Number of pages14
JournalRussian Journal of General Chemistry
Volume84
Issue number1
DOIs
Publication statusPublished - 1 Jan 2014

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Penicillin G
Coordination Complexes
Fungi
Magnetic susceptibility
Metal ions
Paramagnetic resonance
Methanol
Bacteria
Potassium
Ligands
Water
Hot Temperature

Cite this

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AB - Seven types of complexes were obtained when penicillin G potassium (pin) was reacted with transition and non-transition metal ions in methanol/distilled water mixed solvent. Magnetic susceptibilities and ESR spectra (CuII complex) of powdered samples indicated that the monomeric form of the complexes in the solid state, and the paramagnetic nature of the CuII, Ni II, MnII, CrIII, CoII, and Fe III complexes is attributable to the octahedral ligitional behavior of the potassium G penicillinate ligand. The antibacterial activity of the metal complexes were tested against some kind of bacteria and fungi strains and compared with penicillin G potassium activity. The possible mechanism of antibacterial action is discussed.

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