Synthesis, spectral, thermal, and antimicrobial studies of transition metal complexes of atorvastatin calcium as a lipid-lowering agent

Moamen S. Refat, Foziah A. Al-Saif

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Herein, the present work comprises the synthesis of atorvastatin calcium (AVT) complexes with various transition metals. Ten kinds of complexes [Cr(AVT)2(Cl)(H2O)]·5H2O (1), [Mn(AVT)2(H2O)2] (2), [Fe(AVT)2(Cl)(H2O)]·9H2O (3), [Co(AVT)2(H2O)2]·8H2O (4), [Ni(AVT)2(H2O)2]·4H2O (5), [Cu(AVT)2(H2O)2] (6), [Zn(AVT)2]·2H2O (7), [Pt(AVT)2(Cl)2] (8), [Au(AVT)3] (9), and [Pd(AVT)(Cl)2] (10) were obtained. The complexes were characterized by different physicochemical, spectroscopic, and elemental analyses. Results suggest that atorvastatin interacts with the metals as a monoanionic bidentate ligand. These complexes were also tested for their antibacterial activity against six different microorganisms, and the results were compared with the parent drug.

Original languageEnglish
Pages (from-to)863-878
Number of pages16
JournalJournal of Thermal Analysis and Calorimetry
Volume120
Issue number1
DOIs
Publication statusPublished - 30 Mar 2015

Fingerprint

Coordination Complexes
Transition metals
lipids
calcium
transition metals
Lipids
synthesis
Hot Temperature
Atorvastatin Calcium
microorganisms
Microorganisms
drugs
Metals
Ligands

Keywords

  • Antimicrobial test
  • Atorvastatin calcium
  • Spectroscopic characterization
  • Thermal studies
  • Transition metals

Cite this

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title = "Synthesis, spectral, thermal, and antimicrobial studies of transition metal complexes of atorvastatin calcium as a lipid-lowering agent",
abstract = "Herein, the present work comprises the synthesis of atorvastatin calcium (AVT) complexes with various transition metals. Ten kinds of complexes [Cr(AVT)2(Cl)(H2O)]·5H2O (1), [Mn(AVT)2(H2O)2] (2), [Fe(AVT)2(Cl)(H2O)]·9H2O (3), [Co(AVT)2(H2O)2]·8H2O (4), [Ni(AVT)2(H2O)2]·4H2O (5), [Cu(AVT)2(H2O)2] (6), [Zn(AVT)2]·2H2O (7), [Pt(AVT)2(Cl)2] (8), [Au(AVT)3] (9), and [Pd(AVT)(Cl)2] (10) were obtained. The complexes were characterized by different physicochemical, spectroscopic, and elemental analyses. Results suggest that atorvastatin interacts with the metals as a monoanionic bidentate ligand. These complexes were also tested for their antibacterial activity against six different microorganisms, and the results were compared with the parent drug.",
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Synthesis, spectral, thermal, and antimicrobial studies of transition metal complexes of atorvastatin calcium as a lipid-lowering agent. / Refat, Moamen S.; Al-Saif, Foziah A.

In: Journal of Thermal Analysis and Calorimetry, Vol. 120, No. 1, 30.03.2015, p. 863-878.

Research output: Contribution to journalArticleResearchpeer-review

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N2 - Herein, the present work comprises the synthesis of atorvastatin calcium (AVT) complexes with various transition metals. Ten kinds of complexes [Cr(AVT)2(Cl)(H2O)]·5H2O (1), [Mn(AVT)2(H2O)2] (2), [Fe(AVT)2(Cl)(H2O)]·9H2O (3), [Co(AVT)2(H2O)2]·8H2O (4), [Ni(AVT)2(H2O)2]·4H2O (5), [Cu(AVT)2(H2O)2] (6), [Zn(AVT)2]·2H2O (7), [Pt(AVT)2(Cl)2] (8), [Au(AVT)3] (9), and [Pd(AVT)(Cl)2] (10) were obtained. The complexes were characterized by different physicochemical, spectroscopic, and elemental analyses. Results suggest that atorvastatin interacts with the metals as a monoanionic bidentate ligand. These complexes were also tested for their antibacterial activity against six different microorganisms, and the results were compared with the parent drug.

AB - Herein, the present work comprises the synthesis of atorvastatin calcium (AVT) complexes with various transition metals. Ten kinds of complexes [Cr(AVT)2(Cl)(H2O)]·5H2O (1), [Mn(AVT)2(H2O)2] (2), [Fe(AVT)2(Cl)(H2O)]·9H2O (3), [Co(AVT)2(H2O)2]·8H2O (4), [Ni(AVT)2(H2O)2]·4H2O (5), [Cu(AVT)2(H2O)2] (6), [Zn(AVT)2]·2H2O (7), [Pt(AVT)2(Cl)2] (8), [Au(AVT)3] (9), and [Pd(AVT)(Cl)2] (10) were obtained. The complexes were characterized by different physicochemical, spectroscopic, and elemental analyses. Results suggest that atorvastatin interacts with the metals as a monoanionic bidentate ligand. These complexes were also tested for their antibacterial activity against six different microorganisms, and the results were compared with the parent drug.

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