Synthesis, spectroscopic, and thermal investigation of transition and non-transition complexes of metformin as potential insulin-mimetic agents

Foziah A. Al-Saif, Moamen S. Refat

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Abstract

Complexes of [Mn(MF)2(Cl)2]·2H2O (1), [Fe(MF)2(Cl)2]Cl·4H2O (2), [Ni(MF·HCl)2(Cl)2]·6H2O (3), [Cu(MF·HCl)2(Cl)2] (4), [Zn(MF·HCl) 2](NO3)2·6H2O (5), [Cd 2(MF·HCl)(Cl)4(H2O)] (6), [Mg(MF·HCl)2(Cl)2]·6H2O (7), [Sr2(MF·HCl)(Cl)4(H2O)] (8), [Ba(MF·HCl)2(Cl)2]·2H2O (9), [Pt(MF)4] (10), [Au(MF)3]Cl3 (11), and [Pd(MF)2]Cl2 (12) were synthesized from Legitional behavior of metformin drug as a diabetic agent. The authenticity of the transition and non-transition metal complexes were characterized by elemental analyses, molar conductivity, (infrared, UV-Vis) spectra, effective magnetic moment in Bohr magnetons, electron spin resonance, thermal analysis, X-ray powder diffraction as well as scanning electron microscopy. Infrared spectral studies as well as elemental analyses revealed the existence of metformin in the base or hydrochloride salt forms in the chelation state acts as a bidentate ligand while the platinum(IV) complex is coordinated through the deprotonation of -NH group. The magnetic and electronic spectra of Mn(II), Fe(III), Ni(II), and Cu(II) complexes suggest an octahedral geometry. Antimicrobial screening of metformin and its complexes were determined against the (G+ and G-) bacteria (Escherichia coli, Staphylococcus aureus, Bacillus subtilis, and Pseudomonas aeruginosa) and fungi (Aspergillus flavus and Candida albicans).

Original languageEnglish
Pages (from-to)2079-2096
Number of pages18
JournalJournal of Thermal Analysis and Calorimetry
Volume111
Issue number3
DOIs
Publication statusPublished - 1 Mar 2013

Fingerprint

insulin
Metformin
Insulin
Bohr magneton
Aspergillus
chelation
pseudomonas
staphylococcus
fungi
Bacillus
hydrochlorides
synthesis
Escherichia
electronic spectra
bacteria
Infrared radiation
electron paramagnetic resonance
Deprotonation
thermal analysis
drugs

Keywords

  • Antimicrobial test
  • Metformin
  • Spectroscopic investigation
  • Thermal studies
  • Transition and non-transition metals

Cite this

@article{f521c4c549a847b7b6ef532f39b7f030,
title = "Synthesis, spectroscopic, and thermal investigation of transition and non-transition complexes of metformin as potential insulin-mimetic agents",
abstract = "Complexes of [Mn(MF)2(Cl)2]·2H2O (1), [Fe(MF)2(Cl)2]Cl·4H2O (2), [Ni(MF·HCl)2(Cl)2]·6H2O (3), [Cu(MF·HCl)2(Cl)2] (4), [Zn(MF·HCl) 2](NO3)2·6H2O (5), [Cd 2(MF·HCl)(Cl)4(H2O)] (6), [Mg(MF·HCl)2(Cl)2]·6H2O (7), [Sr2(MF·HCl)(Cl)4(H2O)] (8), [Ba(MF·HCl)2(Cl)2]·2H2O (9), [Pt(MF)4] (10), [Au(MF)3]Cl3 (11), and [Pd(MF)2]Cl2 (12) were synthesized from Legitional behavior of metformin drug as a diabetic agent. The authenticity of the transition and non-transition metal complexes were characterized by elemental analyses, molar conductivity, (infrared, UV-Vis) spectra, effective magnetic moment in Bohr magnetons, electron spin resonance, thermal analysis, X-ray powder diffraction as well as scanning electron microscopy. Infrared spectral studies as well as elemental analyses revealed the existence of metformin in the base or hydrochloride salt forms in the chelation state acts as a bidentate ligand while the platinum(IV) complex is coordinated through the deprotonation of -NH group. The magnetic and electronic spectra of Mn(II), Fe(III), Ni(II), and Cu(II) complexes suggest an octahedral geometry. Antimicrobial screening of metformin and its complexes were determined against the (G+ and G-) bacteria (Escherichia coli, Staphylococcus aureus, Bacillus subtilis, and Pseudomonas aeruginosa) and fungi (Aspergillus flavus and Candida albicans).",
keywords = "Antimicrobial test, Metformin, Spectroscopic investigation, Thermal studies, Transition and non-transition metals",
author = "Al-Saif, {Foziah A.} and Refat, {Moamen S.}",
year = "2013",
month = "3",
day = "1",
doi = "10.1007/s10973-012-2459-3",
language = "English",
volume = "111",
pages = "2079--2096",
journal = "Journal of Thermal Analysis and Calorimetry",
issn = "1388-6150",
publisher = "Springer Netherlands",
number = "3",

}

Synthesis, spectroscopic, and thermal investigation of transition and non-transition complexes of metformin as potential insulin-mimetic agents. / Al-Saif, Foziah A.; Refat, Moamen S.

In: Journal of Thermal Analysis and Calorimetry, Vol. 111, No. 3, 01.03.2013, p. 2079-2096.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Synthesis, spectroscopic, and thermal investigation of transition and non-transition complexes of metformin as potential insulin-mimetic agents

AU - Al-Saif, Foziah A.

AU - Refat, Moamen S.

PY - 2013/3/1

Y1 - 2013/3/1

N2 - Complexes of [Mn(MF)2(Cl)2]·2H2O (1), [Fe(MF)2(Cl)2]Cl·4H2O (2), [Ni(MF·HCl)2(Cl)2]·6H2O (3), [Cu(MF·HCl)2(Cl)2] (4), [Zn(MF·HCl) 2](NO3)2·6H2O (5), [Cd 2(MF·HCl)(Cl)4(H2O)] (6), [Mg(MF·HCl)2(Cl)2]·6H2O (7), [Sr2(MF·HCl)(Cl)4(H2O)] (8), [Ba(MF·HCl)2(Cl)2]·2H2O (9), [Pt(MF)4] (10), [Au(MF)3]Cl3 (11), and [Pd(MF)2]Cl2 (12) were synthesized from Legitional behavior of metformin drug as a diabetic agent. The authenticity of the transition and non-transition metal complexes were characterized by elemental analyses, molar conductivity, (infrared, UV-Vis) spectra, effective magnetic moment in Bohr magnetons, electron spin resonance, thermal analysis, X-ray powder diffraction as well as scanning electron microscopy. Infrared spectral studies as well as elemental analyses revealed the existence of metformin in the base or hydrochloride salt forms in the chelation state acts as a bidentate ligand while the platinum(IV) complex is coordinated through the deprotonation of -NH group. The magnetic and electronic spectra of Mn(II), Fe(III), Ni(II), and Cu(II) complexes suggest an octahedral geometry. Antimicrobial screening of metformin and its complexes were determined against the (G+ and G-) bacteria (Escherichia coli, Staphylococcus aureus, Bacillus subtilis, and Pseudomonas aeruginosa) and fungi (Aspergillus flavus and Candida albicans).

AB - Complexes of [Mn(MF)2(Cl)2]·2H2O (1), [Fe(MF)2(Cl)2]Cl·4H2O (2), [Ni(MF·HCl)2(Cl)2]·6H2O (3), [Cu(MF·HCl)2(Cl)2] (4), [Zn(MF·HCl) 2](NO3)2·6H2O (5), [Cd 2(MF·HCl)(Cl)4(H2O)] (6), [Mg(MF·HCl)2(Cl)2]·6H2O (7), [Sr2(MF·HCl)(Cl)4(H2O)] (8), [Ba(MF·HCl)2(Cl)2]·2H2O (9), [Pt(MF)4] (10), [Au(MF)3]Cl3 (11), and [Pd(MF)2]Cl2 (12) were synthesized from Legitional behavior of metformin drug as a diabetic agent. The authenticity of the transition and non-transition metal complexes were characterized by elemental analyses, molar conductivity, (infrared, UV-Vis) spectra, effective magnetic moment in Bohr magnetons, electron spin resonance, thermal analysis, X-ray powder diffraction as well as scanning electron microscopy. Infrared spectral studies as well as elemental analyses revealed the existence of metformin in the base or hydrochloride salt forms in the chelation state acts as a bidentate ligand while the platinum(IV) complex is coordinated through the deprotonation of -NH group. The magnetic and electronic spectra of Mn(II), Fe(III), Ni(II), and Cu(II) complexes suggest an octahedral geometry. Antimicrobial screening of metformin and its complexes were determined against the (G+ and G-) bacteria (Escherichia coli, Staphylococcus aureus, Bacillus subtilis, and Pseudomonas aeruginosa) and fungi (Aspergillus flavus and Candida albicans).

KW - Antimicrobial test

KW - Metformin

KW - Spectroscopic investigation

KW - Thermal studies

KW - Transition and non-transition metals

UR - http://www.scopus.com/inward/record.url?scp=84881480802&partnerID=8YFLogxK

U2 - 10.1007/s10973-012-2459-3

DO - 10.1007/s10973-012-2459-3

M3 - Article

VL - 111

SP - 2079

EP - 2096

JO - Journal of Thermal Analysis and Calorimetry

JF - Journal of Thermal Analysis and Calorimetry

SN - 1388-6150

IS - 3

ER -