Topical simvastatin gel as a novel therapeutic modality for palatal donor site wound healing following free gingival graft procedure

Marwa Madi, Abeer Kassem

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Objective: Autogenous soft-tissue grafting is a commonly used procedure nowadays in dentistry. However, the prolonged healing time needed for the donor site leads to increase the patient’s pain and discomfort. Statin has been observed to be beneficial in reducing bacterial burden, improving epithelization and wound healing. The aim of this study was to evaluate intra-oral topical application of simvastatin/chitosan gel (10 mg/mL) over the palatal donor site following free gingival graft (FGG) procedure. Material and methods: Subjects indicated for FGG procedure were divided into four groups. Group I: Simvastatin suspension (S), group II: simvastatin/chitosan gel (SC), group III: chitosan gel (C), group IV: petroleum gel (P). Treatment was applied three times/day for the following 7 days. Wound healing was evaluated at day 3, 7 and 14 post-surgery. A visual analogue scale (VAS) was used to measure the experienced discomfort at 1, 3, 5, 7 and 14 days. Results: Statistical significant reduction in wound-healing scores was observed after 3 and 7 days for group II compared to other groups (p =.015). A significant reduction was also observed in VAS score for group II compared to other groups at day 1, 3, 5 and 7. Conclusion: Topical application of S/C gel could be used as a novel therapeutic modality that improved healing and reduced pain in the palatal donor site following FGG procedure.

Original languageEnglish
Pages (from-to)212-219
Number of pages8
JournalActa Odontologica Scandinavica
Volume76
Issue number3
DOIs
Publication statusPublished - 3 Apr 2018

Fingerprint

Simvastatin
Wound Healing
Gels
Tissue Donors
Transplants
Visual Analog Scale
Therapeutics
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Tissue Transplantation
Pain
Petroleum
Dentistry
Suspensions

Keywords

  • chitosan
  • Graft
  • healing
  • palate
  • simvastatin
  • wound

Cite this

@article{d2cee8bbc9f0406b9297ba069f2acc6f,
title = "Topical simvastatin gel as a novel therapeutic modality for palatal donor site wound healing following free gingival graft procedure",
abstract = "Objective: Autogenous soft-tissue grafting is a commonly used procedure nowadays in dentistry. However, the prolonged healing time needed for the donor site leads to increase the patient’s pain and discomfort. Statin has been observed to be beneficial in reducing bacterial burden, improving epithelization and wound healing. The aim of this study was to evaluate intra-oral topical application of simvastatin/chitosan gel (10 mg/mL) over the palatal donor site following free gingival graft (FGG) procedure. Material and methods: Subjects indicated for FGG procedure were divided into four groups. Group I: Simvastatin suspension (S), group II: simvastatin/chitosan gel (SC), group III: chitosan gel (C), group IV: petroleum gel (P). Treatment was applied three times/day for the following 7 days. Wound healing was evaluated at day 3, 7 and 14 post-surgery. A visual analogue scale (VAS) was used to measure the experienced discomfort at 1, 3, 5, 7 and 14 days. Results: Statistical significant reduction in wound-healing scores was observed after 3 and 7 days for group II compared to other groups (p =.015). A significant reduction was also observed in VAS score for group II compared to other groups at day 1, 3, 5 and 7. Conclusion: Topical application of S/C gel could be used as a novel therapeutic modality that improved healing and reduced pain in the palatal donor site following FGG procedure.",
keywords = "chitosan, Graft, healing, palate, simvastatin, wound",
author = "Marwa Madi and Abeer Kassem",
year = "2018",
month = "4",
day = "3",
doi = "10.1080/00016357.2017.1403648",
language = "English",
volume = "76",
pages = "212--219",
journal = "Acta Odontologica Scandinavica",
issn = "0001-6357",
publisher = "Informa Healthcare",
number = "3",

}

Topical simvastatin gel as a novel therapeutic modality for palatal donor site wound healing following free gingival graft procedure. / Madi, Marwa; Kassem, Abeer.

In: Acta Odontologica Scandinavica, Vol. 76, No. 3, 03.04.2018, p. 212-219.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Topical simvastatin gel as a novel therapeutic modality for palatal donor site wound healing following free gingival graft procedure

AU - Madi, Marwa

AU - Kassem, Abeer

PY - 2018/4/3

Y1 - 2018/4/3

N2 - Objective: Autogenous soft-tissue grafting is a commonly used procedure nowadays in dentistry. However, the prolonged healing time needed for the donor site leads to increase the patient’s pain and discomfort. Statin has been observed to be beneficial in reducing bacterial burden, improving epithelization and wound healing. The aim of this study was to evaluate intra-oral topical application of simvastatin/chitosan gel (10 mg/mL) over the palatal donor site following free gingival graft (FGG) procedure. Material and methods: Subjects indicated for FGG procedure were divided into four groups. Group I: Simvastatin suspension (S), group II: simvastatin/chitosan gel (SC), group III: chitosan gel (C), group IV: petroleum gel (P). Treatment was applied three times/day for the following 7 days. Wound healing was evaluated at day 3, 7 and 14 post-surgery. A visual analogue scale (VAS) was used to measure the experienced discomfort at 1, 3, 5, 7 and 14 days. Results: Statistical significant reduction in wound-healing scores was observed after 3 and 7 days for group II compared to other groups (p =.015). A significant reduction was also observed in VAS score for group II compared to other groups at day 1, 3, 5 and 7. Conclusion: Topical application of S/C gel could be used as a novel therapeutic modality that improved healing and reduced pain in the palatal donor site following FGG procedure.

AB - Objective: Autogenous soft-tissue grafting is a commonly used procedure nowadays in dentistry. However, the prolonged healing time needed for the donor site leads to increase the patient’s pain and discomfort. Statin has been observed to be beneficial in reducing bacterial burden, improving epithelization and wound healing. The aim of this study was to evaluate intra-oral topical application of simvastatin/chitosan gel (10 mg/mL) over the palatal donor site following free gingival graft (FGG) procedure. Material and methods: Subjects indicated for FGG procedure were divided into four groups. Group I: Simvastatin suspension (S), group II: simvastatin/chitosan gel (SC), group III: chitosan gel (C), group IV: petroleum gel (P). Treatment was applied three times/day for the following 7 days. Wound healing was evaluated at day 3, 7 and 14 post-surgery. A visual analogue scale (VAS) was used to measure the experienced discomfort at 1, 3, 5, 7 and 14 days. Results: Statistical significant reduction in wound-healing scores was observed after 3 and 7 days for group II compared to other groups (p =.015). A significant reduction was also observed in VAS score for group II compared to other groups at day 1, 3, 5 and 7. Conclusion: Topical application of S/C gel could be used as a novel therapeutic modality that improved healing and reduced pain in the palatal donor site following FGG procedure.

KW - chitosan

KW - Graft

KW - healing

KW - palate

KW - simvastatin

KW - wound

UR - http://www.scopus.com/inward/record.url?scp=85034266098&partnerID=8YFLogxK

U2 - 10.1080/00016357.2017.1403648

DO - 10.1080/00016357.2017.1403648

M3 - Article

VL - 76

SP - 212

EP - 219

JO - Acta Odontologica Scandinavica

JF - Acta Odontologica Scandinavica

SN - 0001-6357

IS - 3

ER -